同胞竞争：MHC II 类家族成员之间的竞争抑制免疫。
Sibling rivalry: competition between MHC class II family members inhibits immunity.
机构信息
Child Health Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.
出版信息
Nat Struct Mol Biol. 2013 Jan;20(1):7-10. doi: 10.1038/nsmb.2484.
Peptide loading of major histocompatibility complex (MHC) class II molecules in the endosomes and lysosomes of antigen-presenting cells is catalyzed by human leukocyte antigen-DM (HLA-DM) and modulated by HLA-DO. In a structural study in this issue, Guce et al. show that HLA-DO is an MHC class II mimic and functions as a competitive and essentially irreversible inhibitor of HLA-DM activity, thereby inhibiting MHC class II antigen presentation.
主要组织相容性复合体 (MHC) Ⅱ类分子在抗原呈递细胞的内体和溶酶体中的肽加载由人类白细胞抗原-DM (HLA-DM) 催化，并受 HLA-DO 调节。在本期的一项结构研究中，Guce 等人表明 HLA-DO 是 MHC Ⅱ类分子的模拟物，作为 HLA-DM 活性的竞争性和本质上不可逆的抑制剂发挥作用，从而抑制 MHC Ⅱ类抗原呈递。
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