Graduate School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa 920-0942, Japan.
Ann Nucl Med. 2013 Apr;27(3):271-8. doi: 10.1007/s12149-012-0681-5. Epub 2013 Jan 4.
Almost all small animal SPECT is performed with pinhole collimators (PH), including single-PH (SPH) and multi-PH (MPH). In the clinical study, not only PH but also parallel-hole collimator (PAH) is often used in planar and SPECT imaging. However, there have been no comparative studies on image quality with various collimators on the small animal imaging. This study compared the basic characteristics of PH and PAH in small animal imaging.
Performance of planar and SPECT images was evaluated using (99m)TcO4(-) and SPH, MPH and PAH with low energy and high resolution on the SPECT/CT scanner FX3200. We measured sensitivity, resolution, concentration linearity and uniformity. Planar imaging of mice with (99m)Tc-labeled mercaptoacetyltriglycine ((99m)Tc-MAG3) was performed using SPH and PAH. SPECT imaging with (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) was performed using all collimators.
With SPH, MPH and PAH, sensitivity was 43.5, 211.2 and 926.5 cps/MBq, respectively, and spatial resolution was 0.60/0.56, non/0.96, 5.20/5.34 mm full-width half maximum (planar/SPECT), respectively. There were marked correlations between the radioactivity counts on images and radioactivity with all collimators. Values of % standard deviation on planar imaging showed small differences between the SPH and PAH, while the values were the smallest on SPECT imaging with MPH. On imaging of mice, SPH yielded high-quality (99m)Tc-MAG3-planar images when compared with PAH. MPH yielded sharper (99m)Tc-MDP-SPECT images than SPH and PAH.
The characteristics of PH and PAH differed on small animal imaging. Although sensitivity was higher with PAH, PH showed higher resolution. Among the PH collimators, SPH was more appropriate for planar imaging, and MPH was more suitable for SPECT imaging in a small animal imaging scanner with CZT detector.
几乎所有小动物 SPECT 都使用针孔准直器 (PH) 进行，包括单 PH (SPH) 和多 PH (MPH)。在临床研究中，平面和 SPECT 成像中不仅经常使用 PH，还经常使用平行孔准直器 (PAH)。然而，在小动物成像中，还没有关于各种准直器的图像质量的比较研究。本研究比较了小动物成像中 PH 和 PAH 的基本特征。
使用低能和高分辨率的 SPECT/CT 扫描仪 FX3200 上的 (99m)TcO4(-) 和 SPH、MPH 和 PAH 对小动物的平面和 SPECT 图像进行性能评估。我们测量了灵敏度、分辨率、浓度线性度和均匀性。使用 SPH 和 PAH 对 (99m)Tc 标记的巯基乙酰三甘氨酸 ((99m)Tc-MAG3) 进行了小鼠的平面成像。使用所有准直器进行了 (99m)Tc-亚甲基二膦酸盐 ((99m)Tc-MDP) 的 SPECT 成像。
使用 SPH、MPH 和 PAH，灵敏度分别为 43.5、211.2 和 926.5 cps/MBq，空间分辨率分别为 0.60/0.56、非/0.96、5.20/5.34mm 全宽半最大值（平面/SPECT）。图像上的放射性计数与所有准直器上的放射性之间存在显著相关性。平面成像的 %标准偏差值在 SPH 和 PAH 之间差异较小，而在 MPH 进行的 SPECT 成像中则最小。在对小鼠的成像中，与 PAH 相比，SPH 产生了高质量的 (99m)Tc-MAG3 平面图像。MPH 产生的 (99m)Tc-MDP-SPECT 图像比 SPH 和 PAH 更清晰。
PH 和 PAH 在小动物成像中的特性不同。尽管 PAH 的灵敏度更高，但 PH 的分辨率更高。在 PH 准直器中，SPH 更适合平面成像，而 MPH 更适合在具有 CZT 探测器的小动物成像扫描仪中进行 SPECT 成像。
