Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Acta Paediatr. 2013 Apr;102(4):356-9. doi: 10.1111/apa.12146. Epub 2013 Jan 21.
The major advantage of salivary cortisol sampling is that it is considerably less invasive than taking a blood sample. However, previous methods of obtaining saliva in premature infants have been poorly tolerated and inaccurate. We describe a simple, non-distressing technique for obtaining saliva samples to assess extremely premature infants' salivary cortisol status.
We prospectively obtained early morning saliva samples from extremely premature infants. Their gestational age ranged between 23 and 27 weeks. Saliva was obtained using four standard universal swabs by placing one swab at a time in the infant's mouth for 1-2 min. No salivary stimulants were used.
There were 65 infants (36 males). Mean gestation was 25.3 ± 1.3 weeks. This technique had a success rate of 85% in obtaining a mean of 150 μL of saliva (range 50-350 μL) by trained staff. No adverse events were recorded.
We describe a novel, safe, non-distressing and effective method of saliva collection for salivary cortisol measurement in extremely premature infants.
唾液皮质醇采样的主要优势在于它比采集血液样本侵入性小得多。然而，以前获取早产儿唾液的方法耐受性差且不准确。我们描述了一种简单、无痛苦的获取唾液样本的技术，以评估极早产儿的唾液皮质醇状态。
我们前瞻性地从极早产儿中获得清晨唾液样本。他们的胎龄在 23 到 27 周之间。使用四个标准的通用拭子通过将一个拭子一次放在婴儿口中 1-2 分钟来获取唾液。不使用唾液刺激剂。
共有 65 名婴儿（36 名男性）。平均胎龄为 25.3 ± 1.3 周。通过训练有素的工作人员，该技术以 85%的成功率获得了 150μL 的平均唾液量（范围 50-350μL）。未记录到不良事件。
我们描述了一种新颖、安全、无痛苦且有效的方法，用于采集极早产儿的唾液进行唾液皮质醇测量。
