Michael R P, Zumpe D, Bonsall R W
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30322.
Horm Behav. 1990 Mar;24(1):71-88. doi: 10.1016/0018-506x(90)90028-v.
To examine whether estradiol might be effective in maintaining sexual behavior after castration or after testosterone withdrawal, we have observed male rhesus monkeys during daily 1-hr tests alternately with each of two ovariectomized, estradiol-treated females (four males, four females, eight male-female pairs, 798 tests). Estradiol (2-5 micrograms/kg sc/day) or vehicle was administered in counterbalanced order immediately after castration and again immediately after withdrawal of testosterone propionate treatments (800 micrograms and 1.6 mg sc/day). There were no significant differences in behavior during vehicle and estradiol treatments to indicate that estradiol helped to maintain male sexual activity. Instead, estradiol treatment tended to interfere with the capacity to intromit. This supported the results of other studies, namely, that the systemic administration of estradiol does not enhance the sexual behavior of castrated male macaques, and raises questions about the role of both aromatization and estrogen receptors in the male primate brain.
为了研究雌二醇在去势后或睾酮撤药后是否对维持性行为有效，我们在每日1小时的测试中观察了雄性恒河猴，测试交替与两只经雌二醇处理的去卵巢雌性进行（4只雄性、4只雌性、8对雌雄组合，共798次测试）。在去势后以及再次停止丙酸睾酮治疗（800微克和1.6毫克皮下注射/天）后，立即以平衡顺序给予雌二醇（2 - 5微克/千克皮下注射/天）或赋形剂。在给予赋形剂和雌二醇治疗期间，行为上没有显著差异，表明雌二醇无助于维持雄性性活动。相反，雌二醇治疗倾向于干扰插入能力。这支持了其他研究的结果，即全身给予雌二醇不会增强去势雄性猕猴的性行为，并对雄性灵长类动物大脑中芳香化作用和雌激素受体的作用提出了疑问。
