甾体糖脂L-644,257是一种有效的非特异性宿主抵抗力增强剂。
Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance.
作者信息
Hagmann W K, Ponpipom M M, Jackson J J, Wood D D, Boltz R C, Zweerink H J
机构信息
Department of Medicinal Chemical Research, Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
出版信息
Int J Immunopharmacol. 1990;12(2):241-6. doi: 10.1016/0192-0561(90)90059-v.
A steroidal glycolipid that enhances the nonspecific cellular response to opportunistic infection in an immunocompromised host has been discovered. A dose dependent response with 6-(5-cholesten-3 beta-yloxy)hexyl 1-thio-beta-D-mannopyranoside, L-644,257, was observed against several infective agents including bacterial, fungal, and viral pathogens in cyclophosphamide-treated mice. A mechanism for this protective action is proposed.
已发现一种甾体糖脂，它可增强免疫功能低下宿主对机会性感染的非特异性细胞反应。在环磷酰胺处理的小鼠中，观察到6-(5-胆甾烯-3β-基氧基)己基1-硫代-β-D-甘露吡喃糖苷（L-644,257）对包括细菌、真菌和病毒病原体在内的几种感染因子有剂量依赖性反应。并提出了这种保护作用的机制。
Zotero 插件