胰腺移植和糖尿病肾病病变的逆转。
Pancreas transplantation and reversal of diabetic nephropathy lesions.
机构信息
Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA.
出版信息
Med Clin North Am. 2013 Jan;97(1):109-14. doi: 10.1016/j.mcna.2012.10.009. Epub 2012 Dec 7.
Abstract
Pancreas transplantation is the only available treatment that has restored long-term (10 or more years) normoglycemia without the risks of severe hypoglycemia, allowing testing of the reversibility of diabetic nephropathy lesions. The authors studied renal structure before and 5 and 10 years after pancreas transplantation in nonuremic patients with long-term type 1 diabetes, with established diabetic nephropathy lesions at baseline. Diabetic glomerular lesions were not significantly changed at 5 years but were dramatically improved after 10 years, with most patients' glomerular structure returning to normal at the 10-year follow-up. These studies also showed that tubulointerstitial remodeling was also possible.
摘要
胰腺移植是唯一可恢复长期（10 年或更长时间）正常血糖而无严重低血糖风险的治疗方法，可用于测试糖尿病肾病病变的可逆性。作者研究了基线时患有长期 1 型糖尿病且已确诊为糖尿病肾病病变的非尿毒症患者在胰腺移植前 5 年和 10 年的肾脏结构。在 5 年后，糖尿病肾小球病变没有明显变化，但在 10 年后显著改善，大多数患者的肾小球结构在 10 年随访时恢复正常。这些研究还表明，肾小管间质重塑也是可能的。
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