Trauma and Orthopaedics, East of England Multi-Professional Deanery, Capital Park, Fulbourn, Cambridge, United Kingdom.
Injury. 2013 Jun;44(6):743-6. doi: 10.1016/j.injury.2012.11.028. Epub 2013 Jan 3.
Over 76,000 patients in the UK sustain a proximal femoral fracture. Clopidogrel is currently the world's second best selling drug. There has been much recent controversy surrounding the optimal time for surgical intervention in this medically challenging group of patients. This consecutive series of 1225 patients from our unit over six years included thirty patients concurrently taking clopidogrel whilst sustaining a hip fracture. Our study demonstrated no significant difference in ASA grade, intra-operative blood loss or subsequent transfusion, post-operative wound complication, or mortality to one year in those taking clopidogrel. The authors therefore advocate timely surgical intervention as rapidly as circumstances allow.
在英国，超过 76000 名患者患有股骨近端骨折。氯吡格雷目前是世界上第二畅销的药物。在这个医疗挑战性很大的患者群体中，关于手术干预的最佳时机，最近有很多争议。我们科室对六年来的 1225 名患者进行了连续研究，其中有 30 名患者同时服用氯吡格雷，并且发生了髋部骨折。我们的研究表明，在服用氯吡格雷的患者中，ASA 分级、术中失血量或随后的输血、术后伤口并发症或一年后的死亡率均无显著差异。因此，作者主张在情况允许的情况下尽快进行手术干预。
