Dasanu Constantin A, Ichim Thomas E, Alexandrescu Doru T
Medical Oncology and Blood Disorders, Saint Francis Hospital and Medical Center, Hartford, CT, USA.
J Oncol Pharm Pract. 2013 Dec;19(4):377-9. doi: 10.1177/1078155212468923. Epub 2013 Jan 4.
Transverse leukonychia (Leukonychia striata or Muehrcke's lines) has been described with the use of several drugs in oncology, mainly chemotherapeutic agents. This condition is thought to represent an abnormality of the vascular nail bed. As the diagnosis is clinical and the condition is self-limited, referral to other specialists is usually not required. We report the first case of transverse leukonychia related to the use of transretinoic acid for acute promyelocytic leukemia. Physician awareness of transverse leukonychia is important in order to reassure the patients and avoid unnecessary (and often not inexpensive) diagnostic work-up.
横向白甲（线状白甲或梅尔克线）已在肿瘤学中与多种药物相关联被描述，主要是化疗药物。这种情况被认为代表甲床血管异常。由于诊断是临床性的且病情具有自限性，通常不需要转诊至其他专科医生。我们报告了首例与使用全反式维甲酸治疗急性早幼粒细胞白血病相关的横向白甲病例。医生对白甲有所认识很重要，以便让患者安心并避免不必要的（且往往费用不菲的）诊断检查。
