Yoshida K, Fujii Y, Ina H, Fujioka S, Maseki T, Abe T
Department of Surgery, Kiryu Welfare General Hospital, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1990 Jan;38(1):86-92.
We studied the effects of the electrolyte composition (K, Ca, Na) and calcium entry blockers of the extracellular fluid on the tension development of isolated canine coronary arterial strips. In 20 mEq/l K solution, 4.7 mEq/l calcium produced coronary artery contraction. This Ca-induced contraction was inhibited dose-dependently by calcium entry blockers-nifedipine, nicardipine, diltiazem and verapamil. In the presence of 20 mEq/l K, the reduction of sodium concentration to 12 mEq/l increased the tension of coronary artery. Calcium entry blockers did not affect this tension development. After 5 or 30 min perfusion of calcium entry blockers, Ca-induced contraction was inhibited. It is concluded that low calcium, high sodium cardioplegic solution or addition of calcium entry blockers may relax the canine coronary artery.
我们研究了细胞外液的电解质组成（钾、钙、钠）以及钙通道阻滞剂对离体犬冠状动脉条张力发展的影响。在20毫当量/升钾溶液中，4.7毫当量/升钙可引起冠状动脉收缩。这种钙诱导的收缩被钙通道阻滞剂硝苯地平、尼卡地平、地尔硫卓和维拉帕米剂量依赖性地抑制。在存在20毫当量/升钾的情况下，将钠浓度降至12毫当量/升会增加冠状动脉的张力。钙通道阻滞剂不影响这种张力发展。在灌注钙通道阻滞剂5或30分钟后，钙诱导的收缩受到抑制。得出的结论是，低钙、高钠心脏停搏液或添加钙通道阻滞剂可能会使犬冠状动脉松弛。
