培养阳性伤寒热病例的临床特征及抗生素敏感性模式研究
Study of Clinical Profile and Antibiotic Sensitivity Pattern in Culture-positive Typhoid Fever Cases.
作者信息
Kumar Ashwini, Pandit Vinay, Shetty Seema, Rao Chythra R, Pattanshetty Sanjay, Samarasinghe Charmaine M
机构信息
Department of Community Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
出版信息
Indian J Community Med. 2012 Oct;37(4):256-8. doi: 10.4103/0970-0218.103475.
BACKGROUND
Salmonella enteric serotype Typhi has created a significant therapeutic problem as these strains have developed resistance to the commonly used antimicrobials for the treatment of typhoid fever.
OBJECTIVES
To assess the clinical profile and sensitivity patterns to anti-typhoid drugs.
MATERIALS AND METHODS
A retrospective analysis of 106 culture-positive typhoid cases admitted in a tertiary care hospital during the years 2005-2008.
RESULTS
Records of 106 patients were evaluated, 83 (78.3%) males and 23 (21.7%) females. Fever was present in all patients. Headache in 63 (59.4%) patients and generalized body ache in 53 (32.5%) patients were the most common symptoms, while spleenomegaly in 47 (44.3%) patients and hepatomegaly in 42 (39.6%) patients were the common presenting signs. A maximum sensitivity of 96.6% was observed with cephalosporins, whereas a resistance of 29.2% was seen with fluoroquinolones.
CONCLUSION
A high degree of sensitivity was noted to chloramphenicol, ampicillin and sulphonamides, showing a trend of roll-back of sensitivity to conventional antibiotics.
背景
伤寒沙门氏菌血清型伤寒杆菌引发了重大的治疗难题，因为这些菌株已对治疗伤寒热常用的抗菌药物产生耐药性。
目的
评估临床特征以及对伤寒药物的敏感性模式。
材料与方法
对2005年至2008年期间一家三级护理医院收治的106例培养阳性伤寒病例进行回顾性分析。
结果
对106例患者的记录进行了评估，其中男性83例（78.3%），女性23例（21.7%）。所有患者均有发热症状。63例（59.4%）患者出现头痛，53例（32.5%）患者出现全身疼痛，这些是最常见的症状；47例（44.3%）患者出现脾肿大，42例（39.6%）患者出现肝肿大，这些是常见的体征。头孢菌素的最大敏感性为96.6%，而氟喹诺酮类药物的耐药率为29.2%。
结论
氯霉素、氨苄西林和磺胺类药物的敏感性较高，显示出对传统抗生素敏感性回升的趋势。
Zotero 插件