Mathura K C, Chaudhary D, Simkhada R, Pradhan M, Shrestha P, Gurubacharya D L
Department of Medicine, Kathmandu Medical College Teaching Hospital.
Kathmandu Univ Med J (KUMJ). 2005 Oct-Dec;3(4):376-9.
The present study was designed to analyze the clinical profile and antibiotic sensitivity pattern in the cases of culture positive typhoid fever.
The study was conducted over a period of 1 year. Total of 46 culture positive cases of Typhoid fever were included in the study. The sensitivity pattern of isolates from blood culture was recorded. The modes of presentation, clinical course, lab investigation reports were also recorded.
Out of 46 cases, 33 (71.7%) were males and 13 (28.3%) were females. Average age of presentation was 26.17 years. Fever was present in all patients. Resistance of S .typhi to amoxycillin, chloramphenicol and co-trimoxazole were significantly high. Ciprofloxacin showed resistance in 2 (4.3%) cases. Sensitivity to ceftriaxone was 100% in our study.
Typhoid fever is one of the most common health problem in Nepal. Various drugs are being used in the treatment of typhoid fever, in the mean time resistance to many of them are emerging. An appropriate antibiotic has to be initiated only after culture sensitivity in typhoid fever.
本研究旨在分析培养阳性伤寒热病例的临床特征及抗生素敏感性模式。
本研究为期1年。共纳入46例培养阳性的伤寒热病例。记录血培养分离株的敏感性模式。还记录了临床表现方式、临床病程及实验室检查报告。
46例病例中，男性33例（71.7%），女性13例（28.3%）。平均发病年龄为26.17岁。所有患者均有发热。伤寒杆菌对阿莫西林、氯霉素和复方新诺明的耐药性显著较高。环丙沙星在2例（4.3%）病例中显示耐药。在我们的研究中，对头孢曲松的敏感性为100%。
伤寒热是尼泊尔最常见的健康问题之一。多种药物用于治疗伤寒热，与此同时，许多药物的耐药性正在出现。伤寒热患者必须在培养敏感性试验后才开始使用合适的抗生素。
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