Ozayar Esra, Degerli Semih, Gulec Handan
Department of Anesthesiology and Reanimation, Kecioren Training and Research Hospital, Ankara, Turkey.
Toxicol Int. 2012 Sep;19(3):319-21. doi: 10.4103/0971-6580.103682.
Tricyclic antidepressant overdose is one of the most common cause of serious drug poisonings. Sometimes amitriptyline intoxication can be difficult to treat with standard treatments. At that case hemodiafiltration (HD) can be an eligible choice. We report a successful treatment of severe case using hemodiafiltration in addition to the supportive measures. Management with gastric lavage, activated charcoal, alkalinization and supportive care is the common approach and not enough for patients in deep coma. We satisfied that HD may have a beneficial role in lethal doses of amitriptyline as an additional therapy.
三环类抗抑郁药过量是严重药物中毒最常见的原因之一。有时，标准治疗方法难以治疗阿米替林中毒。在这种情况下，血液透析滤过（HD）可能是一种合适的选择。我们报告了一例使用血液透析滤过联合支持措施成功治疗严重病例的情况。采用洗胃、活性炭、碱化及支持治疗是常见的方法，但对于深度昏迷的患者来说并不足够。我们认为，血液透析滤过作为一种额外的治疗方法，对于致死剂量的阿米替林可能具有有益作用。
