National MS Center, Vanheylenstraat 16, 1820 Melsbroek, Belgium; Department of Neurology UZ Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium.
J Neurol Sci. 2013 Feb 15;325(1-2):120-6. doi: 10.1016/j.jns.2012.12.018. Epub 2013 Jan 4.
Health behavior may be associated with disability progression in multiple sclerosis (MS).
To investigate health-promoting behavior as measured by the Health-Promoting Lifestyle Profile II, which includes the subscales of health responsibility, physical activity, nutrition, spiritual growth, interpersonal relationships and stress management.
We conducted a cross-sectional survey among individuals with MS, registered by the Flemish MS society, Belgium. Scores for the total scale and subscales were categorized into quintiles. A time-to-event analysis and Cox proportional hazard regression were performed with time to Expanded Disability Status Score (EDSS) of 6 (requires a cane) as an outcome measure. Hazard ratios for the time from onset and the time from birth were adjusted for gender, age at onset and immunomodulatory treatment. The first category was the reference group (first quintile).
Data on 1372 respondents with definite MS were collected. Subjects with relapsing onset MS and higher scores for overall health-promoting behavior, and the subscales of physical activity, nutrition and spiritual growth, had a reduced risk of reaching EDSS 6 compared to the reference group. No associations were found for the subscales of health responsibility, stress management and interpersonal relations. In progressive onset MS, no significant associations were obtained.
Our study shows an association of self-reported health promoting behavior with disability progression in subjects with relapsing onset MS.
健康行为可能与多发性硬化症（MS）的残疾进展有关。
研究健康促进行为，采用健康促进生活方式量表 II 进行测量，包括健康责任、身体活动、营养、精神成长、人际关系和压力管理等分量表。
我们对比利时佛兰芒多发性硬化症协会登记的 MS 患者进行了横断面调查。将总评分和分量表评分分为五分位数。以扩展残疾状况评分（EDSS）达到 6 分为结局指标（需要使用拐杖）进行生存时间分析和 Cox 比例风险回归分析。从发病开始和从出生开始的时间的风险比调整了性别、发病年龄和免疫调节治疗。第一类是参考组（第一五分位数）。
共收集了 1372 名明确诊断为 MS 的患者的数据。与参考组相比，复发型 MS 患者和整体健康促进行为评分较高，以及身体活动、营养和精神成长分量表评分较高的患者，达到 EDSS 6 的风险较低。健康责任、压力管理和人际关系分量表与残疾进展无显著关联。在进行性 MS 患者中，未发现显著关联。
我们的研究表明，报告的健康促进行为与复发型 MS 患者的残疾进展有关。
