Shibouta Y, Inada Y, Terashita Z I, Nishikawa K, Kikuchi S
Eur J Pharmacol. 1978 Jan 15;47(2):149-57. doi: 10.1016/0014-2999(78)90386-2.
The beta1- and beta2-components in antidiuresis and sodium retention induced by beta-adrenergic agonists were analysed in ethanol-anesthetized, water-diuretic rats. Intravenous infusions of isoprenaline, salbutamol and carbuterol did not affect insulin clearance but increased plasma renin concentration to the same same extent. Propranolol completely blocked the decreases in urine volume (V) and urinary sodium excretion (UNaV) induced by isoprenaline; practolol (beta1-blocker) inhibited only the decrease in UNaV and butaxamine (beta2-blocker) inhibited only the decrease in V. The ratios of doses of beta-agonists which decreased UNaV and by 50% (ED50 UNaV decrease/ED50 V decrease) were 0.34, 0.68, 1.56 and 2.36 for isoprenaline, tretoquinol, salbutamol and carbuterol, respectively. This increasing order of the ratios coincided with the order reported for the preponderance of the beta2- over beta1-component of these agonists. These results indicate that the decrease in UNaV induced by beta-agonists is related to beta1 stimulation, while the decrease in V is related to beta2 stimulation.
在乙醇麻醉的水利尿大鼠中，分析了β-肾上腺素能激动剂诱导的抗利尿和钠潴留中的β1和β2成分。静脉输注异丙肾上腺素、沙丁胺醇和卡布特罗不影响胰岛素清除率，但使血浆肾素浓度升高至相同程度。普萘洛尔完全阻断了异丙肾上腺素诱导的尿量（V）和尿钠排泄（UNaV）的减少；普拉洛尔（β1受体阻滞剂）仅抑制UNaV的减少，而布他沙明（β2受体阻滞剂）仅抑制V的减少。使UNaV降低50%的β-激动剂剂量与使V降低50%的剂量之比（ED50 UNaV降低/ED50 V降低），异丙肾上腺素、曲托喹酚、沙丁胺醇和卡布特罗分别为0.34、0.68、1.56和2.36。该比值的递增顺序与这些激动剂中β2成分相对于β1成分占优势的报道顺序一致。这些结果表明，β-激动剂诱导的UNaV降低与β1刺激有关，而V的降低与β2刺激有关。
