硫化氢：衰老和与衰老相关疾病的下一个有力预防和治疗药物。
Hydrogen sulfide, the next potent preventive and therapeutic agent in aging and age-associated diseases.
机构信息
Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City, Hunan Province, People's Republic of China.
出版信息
Mol Cell Biol. 2013 Mar;33(6):1104-13. doi: 10.1128/MCB.01215-12. Epub 2013 Jan 7.
Abstract
Hydrogen sulfide (H(2)S) is the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-γ-lyase, cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase. H(2)S has been gaining increasing attention as an important endogenous signaling molecule because of its significant effects on the cardiovascular and nervous systems. Substantial evidence shows that H(2)S is involved in aging by inhibiting free-radical reactions, activating SIRT1, and probably interacting with the age-related gene Klotho. Moreover, H(2)S has been shown to have therapeutic potential in age-associated diseases. This article provides an overview of the physiological functions and effects of H(2)S in aging and age-associated diseases, and proposes the potential health and therapeutic benefits of H(2)S.
摘要
硫化氢 (H₂S) 是继一氧化氮和一氧化碳之后的第三种内源性信号气体递质。它由胱硫醚-γ-裂解酶、胱硫醚-β-合酶和 3-巯基丙酮酸硫转移酶生理生成。由于其对心血管和神经系统的重要影响，H₂S 作为一种重要的内源性信号分子引起了越来越多的关注。大量证据表明，H₂S 通过抑制自由基反应、激活 SIRT1 以及可能与与年龄相关的基因 Klotho 相互作用而参与衰老。此外，H₂S 已被证明在与年龄相关的疾病中有治疗潜力。本文概述了 H₂S 在衰老和与年龄相关的疾病中的生理功能和作用，并提出了 H₂S 的潜在健康和治疗益处。
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