Ivnitskiĭ Iu Iu, Moiseev N Ia
Kosm Biol Aviakosm Med. 1990 Jan-Feb;24(1):32-4.
Resistance of mice to altitude, gas, hemic, tissue, mixed or hyperoxis hypoxia, to oxidative phosphorylation uncoupling agents and to X-ray irradiation during 2 days after exposure to severe acute hypobaric hypoxia was investigated. No significant changes were found in animal resistance to hemic and tissue hypoxia and to oxidative phosphorylation uncoupling agents. Resistance to hypoxic hypoxia was 2.5 times higher at the 2nd hour of the posthypoxic period and returned to the baseline by the 24 th hour. Resistance to sodium nitrite and potassium persulphate that cause hypoxia of mixed type, to hyperoxia and X-raying increased significantly by the 24th hour and returned to the baseline by the 48th hour of the posthypoxic period. The potential role of the antioxidative system in the induction of resistance to oxidative agents and X-ray irradiation during the posthypoxic period is discussed.
研究了小鼠在暴露于严重急性低压缺氧后2天内对海拔、气体、血液、组织、混合或高氧性缺氧、氧化磷酸化解偶联剂以及X射线辐射的抵抗力。未发现动物对血液和组织缺氧以及氧化磷酸化解偶联剂的抵抗力有显著变化。在缺氧后第2小时，对低氧性缺氧的抵抗力提高了2.5倍，并在第24小时恢复到基线水平。对引起混合型缺氧的亚硝酸钠和过硫酸钾、高氧和X射线照射的抵抗力在缺氧后第24小时显著增加，并在缺氧后第48小时恢复到基线水平。讨论了抗氧化系统在缺氧后时期诱导对氧化试剂和X射线辐射抵抗力中的潜在作用。
