Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Trends Parasitol. 2013 Mar;29(3):119-28. doi: 10.1016/j.pt.2012.12.001. Epub 2013 Jan 5.
The complement system is one of the major innate defense mechanisms Borrelia burgdorferi sensu lato has to overcome to establish an infection of mammalian hosts and to cause Lyme borreliosis in humans. Borrelia prevents complement-mediated killing during host colonization through (i) recruitment of host complement regulators by Borrelia, (ii) evasion mechanisms by Borrelia itself, and (iii) exploitation of tick proteins by Borrelia. These interactions with complement can be host species-specific. This review provides an overview of interactions between Borrelia, tick, and host leading to evasion of complement-mediated killing.
补体系统是伯氏疏螺旋体属（Borrelia burgdorferi sensu lato）克服的主要固有防御机制之一，以在哺乳动物宿主体内建立感染并引起人类莱姆病。在宿主定植过程中，伯氏疏螺旋体通过以下方式防止补体介导的杀伤：（i）通过伯氏疏螺旋体招募宿主补体调节剂，（ii）伯氏疏螺旋体自身的逃避机制，以及（iii）伯氏疏螺旋体利用蜱蛋白。这些与补体的相互作用可能具有宿主物种特异性。本综述概述了伯氏疏螺旋体、蜱和宿主之间的相互作用，导致逃避补体介导的杀伤。
