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肿瘤坏死因子α-238G/A（rs361525）基因多态性预测了伴有前驱糖尿病的印度东部人群向 2 型糖尿病的进展。

Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes.

机构信息

Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, 244 AJC Bose Road, Kolkata, India.

出版信息

Diabetes Res Clin Pract. 2013 Mar;99(3):e37-41. doi: 10.1016/j.diabres.2012.12.007. Epub 2013 Jan 5.

DOI:10.1016/j.diabres.2012.12.007
PMID:23298660
Abstract

Prediabetes (IPD; n=122) and normoglycemic individuals (n=100) underwent assessment of polymorphisms of TNFα (-238, -308) and IL6 (-174). After 27.25±5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNFα -238AA/GA genotypes were significantly more common in IPD, had higher TNFα, higher progression to diabetes and lower reversal.

摘要

122 名糖尿病前期（IPD）患者和 100 名血糖正常个体接受了 TNFα（-238、-308）和 IL6（-174）多态性评估。27.25±5.64 个月后，16 名 IPD 患者血糖恢复正常，18 名患者进展为糖尿病。IPD 中 TNFα-238AA/GA 基因型更为常见，TNFα 水平更高，进展为糖尿病的风险更高，逆转的可能性更低。

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