Karande S, Venkataraman R
Department of Pediatrics, Division of Pediatric Neurology, Learning Disability Clinic, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.
J Postgrad Med. 2012 Oct-Dec;58(4):246-54. doi: 10.4103/0022-3859.105442.
Specific learning disability (SpLD) often remains undetected, resulting in the afflicted child experiencing chronic poor school performance.
To measure and analyze the self-perceived health-related quality of life (HRQoL) of children with newly-diagnosed SpLD.
Cross-sectional questionnaire-based study in our clinic.
From February to December 2008, 150 children consecutively diagnosed as having SpLD were enrolled and their HRQoL documented using the DISABKIDS chronic generic module self-report version instrument.
Multiple regression analysis was carried out for determining the 'independent' impact that each of the clinical and socio-demographic variables had on a poor facet score outcome and on a poor total score outcome.
Clinically significant deficits were detected in all 6 facets, namely: 'large deficits (effect size ≥-0.8)' in "social exclusion", "emotion", "limitation", "treatment", and "independence"; and 'medium deficit (effect size -0.5 to <-0.8)' in "social inclusion"; and 'large deficit' in "total score". Multivariate analysis revealed that: (i) not belonging to the upper socio-economic strata of society was an independent predictor of a poor "independence" facet outcome (P=0.010, OR=1.99, 95% CI: 1.18 to 3.37); (ii) not having experienced class detainment was an independent predictor of a poor "emotion" facet outcome (P=0.008, OR=3.04, 95% CI: 1.34 to 6.85); (iii) first-born status was an independent predictor of a poor "limitation" facet outcome (P=0.022, OR=2.60, 95% CI: 1.15 to 5.90); and (iv) female gender was an independent predictor of a poor "social exclusion" facet outcome (P=0.024, OR=0.28, 95% CI: 0.09 to 0.85) and a poor "overall health" outcome (P=0.025, OR=0.32, 95% CI: 0.12 to 0.87).
Children with newly-diagnosed SpLD perceive their psychosocial, physical, and overall HRQoL to be significantly compromised.
特定学习障碍（SpLD）常常未被发现，导致患病儿童长期学业成绩不佳。
测量并分析新诊断出的特定学习障碍儿童自我感知的健康相关生活质量（HRQoL）。
在我们诊所进行的基于问卷调查的横断面研究。
2008年2月至12月，连续纳入150名被诊断为患有特定学习障碍的儿童，并使用儿童残疾通用模块自我报告版工具记录他们的健康相关生活质量。
进行多元回归分析，以确定每个临床和社会人口统计学变量对不良方面得分结果和不良总分结果的“独立”影响。
在所有6个方面均检测到具有临床意义的缺陷，即：“社会排斥”“情绪”“限制”“治疗”和“独立”方面存在“巨大缺陷（效应量≥ -0.8）”；“社会融入”方面存在“中等缺陷（效应量 -0.5至< -0.8）”；“总分”方面存在“巨大缺陷”。多变量分析显示：（i）不属于社会经济上层阶层是“独立”方面不良结果的独立预测因素（P = 0.010，OR = 1.99，95%可信区间：1.18至3.37）；（ii）未经历过班级留校是“情绪”方面不良结果的独立预测因素（P = 0.008，OR = 3.04，95%可信区间：1.34至6.85）；（iii）头胎身份是“限制”方面不良结果的独立预测因素（P = 0.022，OR = 2.60，95%可信区间：1.15至5.90）；（iv）女性性别是“社会排斥”方面不良结果（P = 0.024，OR = 0.28，95%可信区间：0.09至0.85）和“总体健康”不良结果（P = 0.025，OR = 0.32，95%可信区间：0.12至0.87）的独立预测因素。
新诊断出的特定学习障碍儿童认为他们的心理社会、身体和总体健康相关生活质量受到显著损害。
