Membrane/Cytoskeleton Signalling Group, Cardiovascular Division, British Heart Foundation, Centre of Research Excellence, King's College London, London SE5 9NU, United Kingdom.
Int J Biochem Cell Biol. 2013 Mar;45(3):550-5. doi: 10.1016/j.biocel.2012.12.023. Epub 2013 Jan 5.
L-selectin is a type I transmembrane cell adhesion molecule that is expressed on the surface of most circulating leukocytes. Studies in L-selectin knockout mice reveal a prominent role for this glycoprotein in health and disease, regulating leucocyte recruitment to peripheral lymph nodes (e.g. naïve T-cells) and sites of acute and chronic inflammation (e.g. monocytes and neutrophils). Clinical trials have revealed L-selectin as a promising target in some acute and chronic inflammatory diseases. Unearthing the intracellular signals that act directly downstream of L-selectin may also expose novel therapeutic targets in a cell type/disease-specific manner. This review will focus on L-selectin-dependent signalling - exploring the different signals that potentially arise from distinct phases of the multi-step adhesion cascade and the contribution of known binding partners of L-selectin in this response.
L-选择素是一种 I 型跨膜细胞黏附分子，存在于大多数循环白细胞的表面。L-选择素敲除小鼠的研究表明，这种糖蛋白在健康和疾病中起着重要作用，调节白细胞向周围淋巴结（如幼稚 T 细胞）和急性及慢性炎症部位（如单核细胞和中性粒细胞）的募集。临床试验表明，L-选择素是某些急性和慢性炎症性疾病有前途的治疗靶点。揭示 L-选择素下游的细胞内信号也可能以细胞类型/疾病特异性的方式揭示新的治疗靶点。这篇综述将重点介绍 L-选择素依赖的信号转导——探讨多步骤黏附级联反应的不同阶段可能产生的不同信号，以及 L-选择素已知结合伙伴在这一反应中的作用。
