Castro D J, Saxton R E, Layfield L J, Fetterman H R, Castro D J, Tartell P B, Robinson J D, To S Y, Nishimura E, Lufkin R B
Division of Head and Neck Surgery, University of California, Los Angeles, School of Medicine.
Laryngoscope. 1990 May;100(5):541-7. doi: 10.1288/00005537-199005000-00019.
The rapid technological advances of magnetic resonance imaging, laser fiberoptics, and compatible probes may allow treatment of deep and sometimes surgically unreachable tumors of the head and neck with minimal morbidity through interstitial laser phototherapy. In this study, a new application of magnetic resonance imaging was developed to monitor and quantify laser-induced tissue damages. Pig skin was exposed to increased levels of argon laser (514.5 nm) at energy densities between 62.5 and 375 J/cm2 as determined by an accurate and reproducible method of dosimetry. Thermal profiles were recorded using an infrared sensor and T1- and T2-weighted magnetic resonance images were taken; afterward, biopsies were performed to quantitate the level of tissue damage. Our results demonstrate that above a certain threshold of laser energy, the magnetic resonance imaging findings are temperature dependent. Appropriate development of a scale matching laser energies, temperature profiles, T1- and T2-weighted magnetic resonance images, and histological quantitation of tissue destruction will allow us to optimize the three-dimensional control and monitoring of laser-tissue interactions.
磁共振成像、激光光纤和兼容探头的快速技术进步，可能使通过间质激光光疗法以最小的发病率治疗头颈部深部且有时手术无法触及的肿瘤成为可能。在本研究中，开发了一种磁共振成像的新应用，以监测和量化激光诱导的组织损伤。通过精确且可重复的剂量测定方法，将猪皮暴露于能量密度在62.5至375 J/cm²之间的氩激光（514.5 nm）增强水平下。使用红外传感器记录热剖面，并拍摄T1加权和T2加权磁共振图像；之后，进行活检以量化组织损伤水平。我们的结果表明，在一定激光能量阈值以上，磁共振成像结果与温度相关。适当开发一个将激光能量、温度剖面、T1加权和T2加权磁共振图像以及组织破坏的组织学定量相匹配的量表，将使我们能够优化对激光与组织相互作用的三维控制和监测。
