Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
J Invest Dermatol. 2013 Jan;133(1):9-11. doi: 10.1038/jid.2012.411.
Transforming growth factor-β1 (TGFβ1) is generally regarded as an anti-inflammatory cytokine. However, previous studies suggest that TGFβ1 can promote immune responses under certain conditions. In this issue, Mohammed et al. report that epidermal keratinocyte-derived TGFβ1 alone can alter homeostasis of multiple cutaneous dendritic cell (DC) subsets, which may enhance skin inflammation. These findings may provide a better understanding of the pathogenesis of inflammatory skin disorders such as psoriasis, although how keratinocyte-derived TGFβ1 regulates cutaneous DCs under physiological and inflammatory conditions should be further addressed.
转化生长因子-β1（TGFβ1）通常被认为是一种抗炎细胞因子。然而，先前的研究表明，TGFβ1 在某些条件下可以促进免疫反应。在本期杂志中，Mohammed 等人报告称，表皮角质形成细胞衍生的 TGFβ1 本身就可以改变多种皮肤树突状细胞（DC）亚群的稳态，从而可能增强皮肤炎症。这些发现可能有助于更好地理解银屑病等炎症性皮肤疾病的发病机制，尽管角质形成细胞衍生的 TGFβ1 在生理和炎症条件下如何调节皮肤 DC 仍有待进一步研究。
