Dermatology Associates, Norwood, MA, USA.
J Invest Dermatol. 2013 Jan;133(1):11-3. doi: 10.1038/jid.2012.442.
Cutaneous pigment formation and aberration in disease are addressed. Dynoodt et al. (this issue) present data on a specific micro RNA that downregulates proteins involved in melanogenesis and melanosome movement. Kim et al. (this issue) present data showing that Wnt signaling is involved in the pathogenesis of melasma. Both articles enhance our understanding of cutaneous pigmentation and point to targets in the development of novel therapeutic modalities.
本文探讨了疾病状态下的皮肤色素形成和异常。Dynoodt 等人（本期）提供了特定 microRNA 下调黑色素生成和黑素小体运动相关蛋白的相关数据。Kim 等人（本期）提供的数据表明 Wnt 信号通路参与了黄褐斑的发病机制。这两篇文章加深了我们对皮肤色素沉着的认识，并为开发新型治疗方法提供了新的靶点。
