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过氧化氢对过十四烷酸的激活作用是导致蛋白酪氨酸磷酸酶 CD45 强烈抑制的原因。

Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.

机构信息

Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.

出版信息

PLoS One. 2012;7(12):e52495. doi: 10.1371/journal.pone.0052495. Epub 2012 Dec 27.

DOI:10.1371/journal.pone.0052495
PMID:23300686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3531430/
Abstract

Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide.

摘要

过氧化氢诱导许多蛋白酪氨酸磷酸酶氧化，从而使其失活。人们发现，在羧酸存在的情况下，过氧化氢能被有效地激活形成更有效的氧化剂-过氧酸。我们发现过氧十四烷酸比过氧化氢更能显著降低 CD45 磷酸酶的酶活性。我们的分子对接计算分析表明，过氧十四烷酸与 CD45 的催化中心的结合亲和力高于过氧化氢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/5dd499cb07b6/pone.0052495.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/7d1cba45c9bb/pone.0052495.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/d9c0be84bec4/pone.0052495.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/4db138f99f9c/pone.0052495.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/5dd499cb07b6/pone.0052495.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/7d1cba45c9bb/pone.0052495.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/d9c0be84bec4/pone.0052495.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/4db138f99f9c/pone.0052495.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8a/3531430/5dd499cb07b6/pone.0052495.g004.jpg

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2
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J Biochem. 2011 Oct;150(4):345-56. doi: 10.1093/jb/mvr104. Epub 2011 Aug 19.
3
Toward the estimation of the absolute quality of individual protein structure models.
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Bioinformatics. 2011 Feb 1;27(3):343-50. doi: 10.1093/bioinformatics/btq662. Epub 2010 Dec 5.
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Physiology (Bethesda). 2009 Oct;24:281-9. doi: 10.1152/physiol.00017.2009.
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