Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
Int J Neurosci. 2013 Jul;123(7):476-9. doi: 10.3109/00207454.2013.764498. Epub 2013 Feb 6.
Multiple sclerosis (MS) is known to be influenced by various environmental factors including cigarette smoking. To identify the impact of smoking on conversion from clinically isolated syndrome (CIS) to clinically definite MS (CDMS), 95 consecutive uniformly treated smoker (n = 31) and nonsmoker (n = 64) CIS patients were evaluated retrospectively. The smoker CIS patients did not differ from nonsmokers by means of demographic and clinical findings. In addition, there was no difference between the two groups with respect to rate and time of conversion to CDMS. However, white matter lesions were detected in magnetic resonance imagings (MRIs) of all smoking versus 54 of 64 (63.5%) nonsmoking CIS patients (p = 0.02). Our results show that smoking does not predict conversion from CIS to CDMS. However, smoking may be associated with the appearance of white matter lesions on MRI at CIS onset.
多发性硬化症 (MS) 已知受到多种环境因素的影响，包括吸烟。为了确定吸烟对从临床孤立综合征 (CIS) 到临床确诊多发性硬化症 (CDMS) 的转化的影响，对 95 例连续接受统一治疗的吸烟 (n = 31) 和非吸烟 (n = 64) CIS 患者进行了回顾性评估。吸烟的 CIS 患者在人口统计学和临床发现方面与非吸烟者没有差异。此外，两组在向 CDMS 转化的速度和时间上也没有差异。然而，在所有吸烟的患者中都检测到了磁共振成像 (MRI) 的脑白质病变，而非吸烟的 CIS 患者中则有 54 例 (63.5%) 检测到脑白质病变 (p = 0.02)。我们的研究结果表明，吸烟不能预测 CIS 向 CDMS 的转化。然而，吸烟可能与 CIS 发病时 MRI 上脑白质病变的出现有关。
