Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin, Bordeaux, France.
Pigment Cell Melanoma Res. 2013 May;26(3):402-7. doi: 10.1111/pcmr.12065. Epub 2013 Jan 30.
The relation of vitiligo/non-segmental vitiligo (NSV) to Koebner's phenomenon is variably appreciated. Our objective was to develop and validate a simple clinical score for Koebner's phenomenon (KP) in patients with vitiligo/NSV. The study population was composed of 351 individuals in the development sample and 285 patients in the validation sample. Seven variables were independently associated with the presence of KP: disease duration of more than 3 yr, forehead + scalp areas, eyelids, wrists, genital + belt areas, knees and tibial crests. The score computed by the weighted sum of the rounded coefficients of these seven variables ranged from 0 to 56 (mean 38.39 ± 22.93). The probability of having KP was computed as follows: exp (-2.37 + 0.1score)/exp [1 + (-2.37 + 0.1score)]. When applying the score to each patient in the validation and the development sample, the score maintained adequate discrimination and calibration (AUC-ROC = 0.78), arguing that KP can be adequately predicted using our score. Further studies should evaluate KP assessed by the K-VSCOR in clinical practice with the aim to determine its association with clinical profile, course and treatment response of vitiligo.
白癜风/非节段性白癜风（NSV）与柯氏现象的关系评价不一。我们的目的是开发和验证一种用于白癜风/NSV 患者的柯氏现象（KP）的简单临床评分。研究人群由开发样本中的 351 名个体和验证样本中的 285 名患者组成。七个变量与 KP 的存在独立相关：疾病持续时间超过 3 年、额头+头皮区域、眼睑、手腕、生殖器+腰带区域、膝盖和胫骨嵴。通过对这七个变量的圆形系数的加权和计算得出的分数范围为 0 到 56（平均值为 38.39±22.93）。KP 的概率计算如下：exp(-2.37+0.1score)/exp[1+(-2.37+0.1score)]。当将评分应用于验证和开发样本中的每个患者时，评分保持了足够的区分度和校准度（AUC-ROC=0.78），这表明可以使用我们的评分来充分预测 KP。进一步的研究应该评估 K-VSCOR 评估的 KP 在临床上，以确定其与白癜风的临床特征、病程和治疗反应的关系。
