Pang Chen-jiu, Wang Li-ya, Peng Hai-ying, Li Jin, Li Shu-yin, Niu Chao, Yin Wei-jing
Henan Eye Institute, Henan Key Laboratory of Keratonosus, Zhengzhou, China.
Zhonghua Yan Ke Za Zhi. 2012 Oct;48(10):924-9.
To analysis the clinical characteristics of corneal interface fluid syndrome (IFS).
This is a retrospective study. During Jun. 2007 to Oct. 2011. Eight cases (12 eyes) of IFS were diagnosed at Henan Eye Institute. The history and complete ophthalmic examination that include Slit-lamp examination, Slit-lamp photography, IOP, anterior segment OCT (AS-OCT), confocal microscopic exams were recorded.
In total 8 cases (12 eyes), 4 cases were bilateral, 4 cases were unilateral. Six patients were male and 2 were female. The age of the patients ranged from 19 to 35 years. Post-lasik steroid-induced elevated IOP was 4 eyes in 2 patients. Primary open angle glaucoma was 4 eyes in 2 patients. 1 patient (1 eye) was Posner-Shlossman syndrome, 1 patient (1 eye) was pigmented glaucoma, 1 patient (1 eye) was post-lasik traumatic iritis. 1 patient (1 eye) got IFS after repeated flap reposition because of epithelium ingrowth. Slit-lamp exam indicated edematous corneal, lamellar haze, interface fluids accumulation. AS-OCT showed obvious interface dark area. Confocal microscopy exam showed edematous corneal flap, more oval and large keratocytes' nuclei but no inflammatory cells.
IFS is a rare but serious complication after LASIK. The main causes are high intraocular pressure and/or dysfunction of corneal endothelium. Careful exam by slit-lamp may help diagnosis, and further AS-OCT and/or in vivo confocal microscopy exam will confirm it.
分析角膜界面液综合征（IFS）的临床特征。
这是一项回顾性研究。在2007年6月至2011年10月期间。河南眼科研究所诊断出8例（12只眼）IFS。记录病史及完整的眼科检查结果，包括裂隙灯检查、裂隙灯照相、眼压、眼前节光学相干断层扫描（AS - OCT）、共焦显微镜检查。
总共8例（12只眼），4例为双眼，4例为单眼。6例患者为男性，2例为女性。患者年龄在19至35岁之间。准分子激光原位角膜磨镶术（LASIK）后激素性眼压升高在2例患者中为4只眼。原发性开角型青光眼在2例患者中为4只眼。1例患者（1只眼）为波斯纳 - 施洛斯曼综合征，1例患者（1只眼）为色素性青光眼，1例患者（1只眼）为LASIK术后外伤性虹膜炎。1例患者（1只眼）因上皮内生反复进行瓣复位后发生IFS。裂隙灯检查显示角膜水肿、板层混浊、界面液积聚。AS - OCT显示明显的界面暗区。共焦显微镜检查显示角膜瓣水肿，角膜细胞的细胞核更多呈椭圆形且较大，但无炎症细胞。
IFS是LASIK术后一种罕见但严重的并发症。主要原因是高眼压和/或角膜内皮功能障碍。裂隙灯仔细检查有助于诊断，进一步的AS - OCT和/或活体共焦显微镜检查将予以确诊。
