牛膝根中的一个新阿魏酰酪胺糖苷。

A new feruloyl tyramine glycoside from the roots of Achyranthes bidentata.

机构信息

Key Laboratory of Chinese Materia Medica (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China.

出版信息

Chin J Nat Med. 2012 Jan;10(1):16-9. doi: 10.1016/S1875-5364(12)60003-X.

DOI:10.1016/S1875-5364(12)60003-X

PMID:23302523

Abstract

AIM

To study the chemical constituents of the roots of Achyranthes bidentata Bl.

METHODS

The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatographies and preparetive HPLC. Their structures were elucidated on the basis of 1D and 2D NMR analyses.

RESULTS

Two feruloyl tyramine glycosides and seven triterpenoid saponins were obtained and identified as N-trans-feruloyl-3-methoxytyramine-4'-O-β-D-glucopyranoside (1), N-trans-feruloyl-3-methoxytyra mine-4-O-β-D-glucopyranoside (2), PJS-1 (3), chikusetsusaponin IVa (4), oleanolic acid 3-O-[β-D-glucuronopy ranoside-6-O-methyl ester]-28-O-β-D-glucopyranoside (5), oleanolic acid 3-O-[β-D-glucuronopyran-oside-6-O-ethylester]-28-O-β-D-glucopyranoside (6), oleanolic acid 3-O-[β-D-glucuronopyranoside-6-O-butyl ester]-28-O-β-D-glucopyranoside (7), ginsenoside R(0) (8) and hederagenin-28-O-β-D-glucopyranosyl ester (9).

CONCLUSION

Compound 1 is a new feruloyl tyramine glycoside, while compounds 2 and 9 are reported from A. bidentata for the first time.

摘要

目的

研究牛膝根的化学成分。

方法

采用大孔吸附树脂 D101、硅胶和 ODS 柱色谱及制备型高效液相色谱等方法对化学成分进行分离纯化，根据 1D 和 2D NMR 分析鉴定其结构。

结果

分离得到 2 个阿魏酰酪胺糖苷和 7 个三萜皂苷，分别鉴定为 N-反式-阿魏酰-3-甲氧基酪胺-4'-O-β-D-吡喃葡萄糖苷（1）、N-反式-阿魏酰-3-甲氧基酪胺-4-O-β-D-吡喃葡萄糖苷（2）、PJS-1（3）、齐墩果酸 3-O-[β-D-吡喃葡萄糖醛酸-6-O-甲酯基]-28-O-β-D-吡喃葡萄糖苷（5）、齐墩果酸 3-O-[β-D-吡喃葡萄糖醛酸-6-O-乙酯基]-28-O-β-D-吡喃葡萄糖苷（6）、齐墩果酸 3-O-[β-D-吡喃葡萄糖醛酸-6-O-丁酯基]-28-O-β-D-吡喃葡萄糖苷（7）、人参皂苷 R（0）（8）和栀子苷元-28-O-β-D-吡喃葡萄糖苷（9）。