栀子根中的三个新三萜皂苷。

Three new triterpenoid saponins from root of Gardenia jasminoides Ellis.

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.

出版信息

Fitoterapia. 2012 Dec;83(8):1396-401. doi: 10.1016/j.fitote.2012.07.004. Epub 2012 Jul 14.

DOI:10.1016/j.fitote.2012.07.004

PMID:22796399

Abstract

Three new compounds (Gardeniside A-C), 11α,12α-epoxy-3β-[(O-β-D-glucuronopyranoside-6'-O-methly ester)oxy]olean-28,13-olide (1), siaresinolic acid 3-O-β-D-glucuronopyranoside-6'-O-methly ester (2), and 3-O-β-D- glucuronopyranoside-6'-O-methly ester-siaresinolic acid-28-O-β-D- glucopyranoside (3), with seven known compounds oleanolic acid 3-O-β-D- glucuronopyranoside-6'-O-methly ester (4), oleanolic acid 3-O-β-D- glucuropyranoside (5), hederagenin 3-O-β-D- glucuronopyranoside-6'-O- methly ester (6), chikusetsusaponin IVa methyl ester (7), chikusetsusaponin (8), chikusetsusaponin IVa butyl ester (9), siaresinolic acid 28-o-β-d-glucopyranosyl ester (10) were isolated from the root of Gardenia jasminoides Ellis. Six compounds (1, 4-7, and 9) showed cytotoxic activities against HeLa, A549, MCF-7 and A354-S2 cell lines.

摘要

从栀子根中分离得到三个新化合物（栀子苷 A-C）、11α,12α-环氧-3β-[(O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯)氧基]齐墩烷-28,13-内酯（1）、栀子酸 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯（2）和 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯-栀子酸-28-O-β-D-吡喃葡萄糖苷（3），以及七个已知化合物齐墩果酸 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯（4）、齐墩果酸 3-O-β-D-吡喃葡萄糖苷（5）、栀子苷 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯（6）、栀子苷 IVa 甲酯（7）、栀子苷（8）、栀子苷 IVa 丁酯（9）、栀子酸 28-O-β-D-吡喃葡萄糖苷酯（10）。化合物 1、4-7 和 9 对 HeLa、A549、MCF-7 和 A354-S2 细胞系表现出细胞毒性活性。