School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.
Fitoterapia. 2012 Dec;83(8):1396-401. doi: 10.1016/j.fitote.2012.07.004. Epub 2012 Jul 14.
Three new compounds (Gardeniside A-C), 11α,12α-epoxy-3β-[(O-β-D-glucuronopyranoside-6'-O-methly ester)oxy]olean-28,13-olide (1), siaresinolic acid 3-O-β-D-glucuronopyranoside-6'-O-methly ester (2), and 3-O-β-D- glucuronopyranoside-6'-O-methly ester-siaresinolic acid-28-O-β-D- glucopyranoside (3), with seven known compounds oleanolic acid 3-O-β-D- glucuronopyranoside-6'-O-methly ester (4), oleanolic acid 3-O-β-D- glucuropyranoside (5), hederagenin 3-O-β-D- glucuronopyranoside-6'-O- methly ester (6), chikusetsusaponin IVa methyl ester (7), chikusetsusaponin (8), chikusetsusaponin IVa butyl ester (9), siaresinolic acid 28-o-β-d-glucopyranosyl ester (10) were isolated from the root of Gardenia jasminoides Ellis. Six compounds (1, 4-7, and 9) showed cytotoxic activities against HeLa, A549, MCF-7 and A354-S2 cell lines.
从栀子根中分离得到三个新化合物（栀子苷 A-C）、11α,12α-环氧-3β-[(O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯)氧基]齐墩烷-28,13-内酯（1）、栀子酸 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯（2）和 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯-栀子酸-28-O-β-D-吡喃葡萄糖苷（3），以及七个已知化合物齐墩果酸 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯（4）、齐墩果酸 3-O-β-D-吡喃葡萄糖苷（5）、栀子苷 3-O-β-D-葡糖醛酸吡喃糖苷-6'-O-甲酯（6）、栀子苷 IVa 甲酯（7）、栀子苷（8）、栀子苷 IVa 丁酯（9）、栀子酸 28-O-β-D-吡喃葡萄糖苷酯（10）。化合物 1、4-7 和 9 对 HeLa、A549、MCF-7 和 A354-S2 细胞系表现出细胞毒性活性。
