Wu Hong, Deng Jie, Qian Yuan, Zhu Ru-nan, Sun Yu, Zhao Lin-qing, Wang Fang, Shan Min-na, Deji Mei-duo
Department of Pediatrics, Tibet Autonomous Region People's Hospital, Lhasa, Tibet 850000, China.
Zhonghua Er Ke Za Zhi. 2012 Oct;50(10):740-2.
To investigate the viral etiology and clinical features of hospitalized children with acute respiratory tract infections in Tibet.
Nasopharyngeal aspirate samples were collected from children with acute respiratory tract infection hospitalized at the department of Pediatrics, Tibet Autonomous Region People's Hospital from April to July, 2011. The specimens of nasopharyngeal aspirate were screened for antigens of 7 common respiratory viruses by direct immunofluorescence (DIF) [respiratory syncytial virus (RSV), adenovirus (ADV), parainfluenza viruses type I-III, influenza virus A and B] and human metapneumovirus. Clinical data of the children were analyzed by statistical software SPSS16.
A total of 167 children with acute respiratory tract infections hospitalized from April to July 2011 were enrolled in this investigation. Sixty-five out of 167 specimens were positive for viral antigens. The virus positive rate for specimens was 38.9% (65/167). Two of 65 positive specimens were positive for 2 virus antigens (RSV + influenza B) and (hMPV + parainfluenza virus type III), respectively. RSV was detected in 45 cases (67.2%, 45/67) which was the most predominant, followed by parainfluenza virus type III detected in 7 cases (10.4%, 7/67), ADV in 6 cases (9.0%, 6/67), parainfluenza virus type I in 4 cases (6.0%, 4/67), influenza virus type B in 3 cases (4.5%, 3/67), and hMPV in 2 cases (3.0%, 2/67). In addition to clinical manifestations of pneumonia, such as cough and shortness of breath, only 3 virus positive cases (6.67%) presented with wheezing, but the signs of severe cyanosis, fine rales in lung were common. Most of the children in this study recovered soon, only a few younger children with underlying diseases or complications had severe illness.
Virus is an important pathogen for acute respiratory infections for hospitalized children in Tibet. RSV was the most predominant etiological agent, especially for those younger than 3 years old.
探讨西藏地区住院急性呼吸道感染患儿的病毒病原学及临床特征。
收集2011年4月至7月在西藏自治区人民医院儿科住院的急性呼吸道感染患儿的鼻咽抽吸物样本。采用直接免疫荧光法（DIF）对鼻咽抽吸物标本进行7种常见呼吸道病毒抗原检测[呼吸道合胞病毒（RSV）、腺病毒（ADV）、1-3型副流感病毒、甲型和乙型流感病毒]以及人偏肺病毒检测。应用统计软件SPSS16对患儿的临床资料进行分析。
本研究共纳入2011年4月至7月住院的167例急性呼吸道感染患儿。167份标本中65份病毒抗原检测阳性，标本病毒阳性率为38.9%（65/167）。65份阳性标本中有2份分别同时检测出2种病毒抗原（RSV + 乙型流感病毒）和（人偏肺病毒 + 3型副流感病毒）。RSV检测出45例（67.2%，45/67），为最主要的病毒，其次是3型副流感病毒7例（10.4%，7/67），ADV 6例（9.0%，6/67），1型副流感病毒4例（6.0%，4/67），乙型流感病毒3例（4.5%，3/67），人偏肺病毒2例（3.0%，2/67）。除肺炎的临床表现如咳嗽、气促外，仅3例病毒阳性患儿（6.67%）出现喘息，但重度发绀、肺部细湿啰音体征常见。本研究中多数患儿恢复较快，仅少数有基础疾病或并发症的年幼儿童病情较重。
病毒是西藏地区住院急性呼吸道感染患儿的重要病原体。RSV是最主要的病原，尤其在3岁以下儿童中。
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