人乳腺癌中NF-κB、雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（Her2/neu）、Ki67、p53表达之间的关系
Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer.
作者信息
Shapochka D O, Zaletok S P, Gnidyuk M I
机构信息
RE Kavetsky Institute of Experimental Pathology Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine.
出版信息
Exp Oncol. 2012 Dec;34(4):358-63.
AIM
The aim of the present study was to investigate expression patterns of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with breast cancer (BC) and analyze correlation between these markers.
PATIENTS AND METHODS
62 BC patients previously not treated with chemo- or radiotherapy were included in the study. All tumors belong to invasive ductal carcinoma of different grade. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections.
RESULTS
The correlation between tumor grade and expression of ER, PR, Ki-67 and p53 was defined. NF-κB expression was found to be changed dependent on expression of ER, PR and p53 and also on molecular subtype (luminal, Her2-positive, hybrid, basal-like). The highest levels of NF-κB, Ki-67 and p53 were found in Her2/neu+ and basal-like tumor subtypes.
CONCLUSION
The increase of nuclear expression of NF-κB correlates with a decrease of expression of steroid hormone receptors (ER and PR), increase of p53 accumulation, and is associated with Her2-positive and basal-like tumor types.
目的
本研究旨在调查乳腺癌（BC）患者肿瘤组织中转录因子NF-κB（p50和p65）、雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2/neu（Her2/neu）、Ki-67和p53的表达模式，并分析这些标志物之间的相关性。
患者与方法
本研究纳入62例未接受过化疗或放疗的BC患者。所有肿瘤均为不同分级的浸润性导管癌。通过对石蜡包埋组织切片进行免疫组织化学分析来确定分子标志物的表达。
结果
确定了肿瘤分级与ER、PR、Ki-67和p53表达之间的相关性。发现NF-κB的表达变化取决于ER、PR和p53的表达，也取决于分子亚型（管腔型、Her2阳性型、混合型、基底样型）。在Her2/neu阳性和基底样肿瘤亚型中发现NF-κB、Ki-67和p53的水平最高。
结论
NF-κB核表达的增加与类固醇激素受体（ER和PR）表达的降低、p53积累的增加相关，并且与Her2阳性和基底样肿瘤类型有关。
Zotero 插件