Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany.
J Hum Genet. 2013 Mar;58(3):155-9. doi: 10.1038/jhg.2012.149. Epub 2013 Jan 10.
The exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. Ten tagging single-nucleotide polymorphisms (SNPs) for PXR and seven for the CAR genes were selected and genotyped in 627 MM cases and 883 controls collected in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium. None of the 17 SNPs investigated showed significant association with MM risk either alone or when combined in haplotypes. Significant SNP-SNP interactions were not found, neither with 58 previously genotyped polymorphisms in ABC transporters. We can therefore exclude that common genetic variants in the xenobiotic transport and metabolism regulator genes PXR and CAR affect MM risk.
暴露于异源生物转运和代谢基因中的杀虫剂和有毒化合物已被证明会影响多发性骨髓瘤 (MM) 的发病风险。因此，我们假设异源生物转运和代谢调节剂基因 PXR（NR1I2）和 CAR（NR1I3）的遗传变异可能决定 MM 易感性的差异。选择了 PXR 和 CAR 基因的 10 个标记单核苷酸多态性 (SNP) 并对国际多发性骨髓瘤 rESEarch (IMMEnSE) 联盟中收集的 627 例 MM 病例和 883 例对照进行了基因分型。在所研究的 17 个 SNP 中，无论是单独还是在单倍型中组合时，都没有发现与 MM 风险显著相关。也没有发现与之前在 ABC 转运体中已分型的 58 个多态性显著的 SNP-SNP 相互作用。因此，我们可以排除异源生物转运和代谢调节剂基因 PXR 和 CAR 中的常见遗传变异会影响 MM 风险。
