Division of Pediatric Infectious Diseases, The University of Alabama, Birmingham, AL 35233, USA.
Am J Perinatol. 2013 Feb;30(2):113-9. doi: 10.1055/s-0032-1332802. Epub 2013 Jan 9.
Genital herpes infections are extremely common worldwide and ~22% of pregnant women are infected with herpes simplex virus. Eighty percent of those affected with genital herpes are unaware of being infected. The most devastating consequence of maternal genital herpes is neonatal herpes disease. Fortunately, neonatal herpes simplex infections are uncommon but due to the morbidity and mortality associated with the infection are often considered in the differential diagnosis of ill neonates. The use of polymerase chain reaction assay for diagnosis of central nervous system infections and the development of safe and effective antiviral therapy have revolutionized the diagnosis and management of these infants. Most recently, the initiation of long-term antiviral suppressive therapy in these infants has led to significant improvement in morbidity. This review will summarize the epidemiology of maternal and neonatal herpes infections and discuss clinical presentation, diagnosis, management, and follow-up of infants with neonatal herpes disease.
生殖器疱疹感染在全球极为常见，约有 22%的孕妇感染单纯疱疹病毒。80%的生殖器疱疹感染者并不知道自己已被感染。母体生殖器疱疹最具破坏性的后果是新生儿疱疹病。幸运的是，新生儿单纯疱疹感染并不常见，但由于与感染相关的发病率和死亡率，常被认为是病新生儿的鉴别诊断之一。聚合酶链反应检测在中枢神经系统感染中的应用以及安全有效的抗病毒治疗的发展，彻底改变了这些婴儿的诊断和管理方式。最近，对这些婴儿进行长期抗病毒抑制治疗，大大降低了发病率。本文将总结母体和新生儿疱疹感染的流行病学，并讨论新生儿疱疹病患儿的临床表现、诊断、治疗和随访。
