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重新利用巴氏涂片:朝着妇科癌症筛查更近一步。

Repurposing the Pap smear: one step closer to gynecologic cancer screening.

机构信息

Department of Gynecologic Oncology and Reproductive Medicine, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.

出版信息

Sci Transl Med. 2013 Jan 9;5(167):167ps1. doi: 10.1126/scitranslmed.3005411.

DOI:10.1126/scitranslmed.3005411
PMID:23303602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3824959/
Abstract

Prevention and early detection remain essential to decreasing cancer mortality. Screening DNA in Pap smears has the potential to increase the rate of early detection of endometrial and ovarian cancers. In this issue of Science Translational Medicine, Kinde and colleagues use advanced sequencing technology to evaluate DNA to screen for gynecologic malignancies.

摘要

预防和早期发现仍然是降低癌症死亡率的关键。在巴氏涂片检查中筛查 DNA 有可能提高子宫内膜癌和卵巢癌的早期检出率。在本期《科学转化医学》中,Kinde 及其同事使用先进的测序技术评估 DNA 以筛查妇科恶性肿瘤。

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Repurposing the Pap smear: one step closer to gynecologic cancer screening.重新利用巴氏涂片:朝着妇科癌症筛查更近一步。
Sci Transl Med. 2013 Jan 9;5(167):167ps1. doi: 10.1126/scitranslmed.3005411.
2
Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.巴氏涂片检查中 DNA 检测对卵巢癌和子宫内膜癌的评估。
Sci Transl Med. 2013 Jan 9;5(167):167ra4. doi: 10.1126/scitranslmed.3004952.
3
Retooling the pap smear for ovarian and endometrial cancer detection.改进巴氏涂片检查以用于卵巢癌和子宫内膜癌的检测。
Clin Chem. 2014 Jan;60(1):22-4. doi: 10.1373/clinchem.2013.204933. Epub 2013 Sep 16.
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Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers.巴氏涂片检查和其他液体活检测试在子宫内膜癌和卵巢癌检测中的评估。
Sci Transl Med. 2018 Mar 21;10(433). doi: 10.1126/scitranslmed.aap8793.
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Incidental finding of abnormal cervical pathology in hysterectomy specimens after normal preoperative Papanicolaou smears in Thammasat University Hospital.在泰国法政大学医院,术前巴氏涂片检查正常的子宫切除标本中意外发现宫颈病理异常。
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The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update.常规巴氏涂片检测子宫内膜癌的诊断价值:最新进展
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Test for ovarian, endometrial cancers. Could cells taken from a Pap test offer the first-ever early screening method?用于卵巢癌和子宫内膜癌的检测。从巴氏涂片检查中获取的细胞能否提供有史以来第一种早期筛查方法?
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A Pap-Based Test to Detect Endometrial and Ovarian Cancers Early.一种用于早期检测子宫内膜癌和卵巢癌的基于巴氏涂片的检测方法。
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Diagn Cytopathol. 2021 Jan;49(1):127-131. doi: 10.1002/dc.24609. Epub 2020 Sep 10.

引用本文的文献

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Curr Oncol. 2017 Oct;24(5):e368-e378. doi: 10.3747/co.24.3594. Epub 2017 Oct 25.

本文引用的文献

1
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.全外显子组测序结合功能基因组学揭示子宫内膜癌中的新型候选驱动癌基因。
Genome Res. 2012 Nov;22(11):2120-9. doi: 10.1101/gr.137596.112. Epub 2012 Oct 1.
2
Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.通过全基因组分析鉴定子宫浆液性癌中的分子通路异常。
J Natl Cancer Inst. 2012 Oct 3;104(19):1503-13. doi: 10.1093/jnci/djs345. Epub 2012 Aug 23.
3
Liquid-based Papanicolaou tests in endometrial carcinoma diagnosis. Performance, error root cause analysis, and quality improvement.
液基巴氏涂片检查在子宫内膜癌诊断中的应用。性能、误差根本原因分析和质量改进。
Am J Clin Pathol. 2012 Feb;137(2):248-54. doi: 10.1309/AJCPLFBK1A2XJDQI.
4
Cancer statistics, 2012.癌症统计数据,2012 年。
CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29. doi: 10.3322/caac.20138. Epub 2012 Jan 4.
5
Quantitative cell-free DNA, KRAS, and BRAF mutations in plasma from patients with metastatic colorectal cancer during treatment with cetuximab and irinotecan.在接受西妥昔单抗和伊立替康治疗的转移性结直肠癌患者的血浆中定量检测游离 DNA、KRAS 和 BRAF 突变。
Clin Cancer Res. 2012 Feb 15;18(4):1177-85. doi: 10.1158/1078-0432.CCR-11-0564. Epub 2012 Jan 6.
6
Genomic analysis of circulating cell-free DNA infers breast cancer dormancy.循环游离 DNA 的基因组分析推断乳腺癌休眠。
Genome Res. 2012 Feb;22(2):220-31. doi: 10.1101/gr.123497.111. Epub 2011 Oct 11.
7
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.子宫内膜癌中 PIK3R1 和 PIK3R2 突变的高频揭示了一种调节 PTEN 蛋白稳定性的新机制。
Cancer Discov. 2011 Jul;1(2):170-85. doi: 10.1158/2159-8290.CD-11-0039. Epub 2011 Jun 7.
8
Integrated genomic analyses of ovarian carcinoma.卵巢癌的综合基因组分析。
Nature. 2011 Jun 29;474(7353):609-15. doi: 10.1038/nature10166.
9
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.筛查对卵巢癌死亡率的影响:前列腺癌、肺癌、结直肠癌和卵巢癌(PLCO)癌症筛查随机对照试验。
JAMA. 2011 Jun 8;305(22):2295-303. doi: 10.1001/jama.2011.766.
10
Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort.经阴道超声筛查绝经后妇女子宫内膜癌的敏感性:英国 CTOCS 队列中的病例对照研究。
Lancet Oncol. 2011 Jan;12(1):38-48. doi: 10.1016/S1470-2045(10)70268-0. Epub 2010 Dec 10.