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Total syntheses of lactonamycin and lactonamycin Z with late-stage A-ring formation and glycosylation.

作者信息

Adachi Satoshi, Watanabe Kana, Iwata Yusuke, Kameda Shunsuke, Miyaoka Yoshihito, Onozuka Masao, Mitsui Ryo, Saikawa Yoko, Nakata Masaya

机构信息

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

出版信息

Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2087-91. doi: 10.1002/anie.201209205. Epub 2013 Jan 9.

DOI:10.1002/anie.201209205
PMID:23303690
Abstract
摘要

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Total syntheses of lactonamycin and lactonamycin Z with late-stage A-ring formation and glycosylation.通过后期A环形成和糖基化实现内酯霉素和内酯霉素Z的全合成。
Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2087-91. doi: 10.1002/anie.201209205. Epub 2013 Jan 9.
2
Studies directed toward the total synthesis of lactonamycin: control of the sense of cycloaddition of a quinone through directed intramolecular catalysis.针对内酯霉素全合成的研究:通过定向分子内催化控制醌的环加成方向。
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Concise synthesis of a lactonamycin model system by diastereoselective dihydroxylation of a highly functionalized naphthoquinone.通过对高度官能化萘醌进行非对映选择性二羟基化简洁合成内酯霉素模型体系。
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Tandem conjugate cyanide addition-Dieckmann condensation in the synthesis of the ABCD-ring system of lactonamycin.
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