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磷脂在胞吞作用、吞噬作用和巨胞饮作用中的作用。

Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis.

机构信息

Division of Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Canada.

出版信息

Physiol Rev. 2013 Jan;93(1):69-106. doi: 10.1152/physrev.00002.2012.

Abstract

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate the expression of surface components. While a great deal of effort has been devoted over many years to understanding the proteins involved in these processes, the important contribution of phospholipids has only recently been appreciated. This review is an attempt to collate and analyze the rapidly emerging evidence documenting the role of phospholipids in clathrin-mediated endocytosis, phagocytosis, and macropinocytosis. A primer on phospholipid biosynthesis, catabolism, subcellular distribution, and transport is presented initially, for reference, together with general considerations of the effects of phospholipids on membrane curvature and charge. This is followed by a detailed analysis of the critical functions of phospholipids in the internalization processes and in the maturation of the resulting vesicles and vacuoles as they progress along the endo-lysosomal pathway.

摘要

内吞作用、吞噬作用和胞饮作用是细胞能够采样其环境、清除病原体和凋亡体以及调节表面成分表达的基本过程。尽管多年来已经投入了大量精力来了解参与这些过程的蛋白质,但最近才意识到磷脂的重要贡献。这篇综述试图整理和分析迅速出现的证据,证明磷脂在网格蛋白介导的内吞作用、吞噬作用和胞饮作用中的作用。首先介绍了磷脂生物合成、分解代谢、亚细胞分布和运输的入门知识,以供参考,并概述了磷脂对膜曲率和电荷的影响。接下来详细分析了磷脂在内化过程中的关键功能,以及在沿着内体-溶酶体途径进行过程中,形成的囊泡和液泡的成熟过程中的关键功能。

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