Seretis Charalampos, Seretis Fotios, Lagoudianakis Emmanuel, Politou Marianna, Gemenetzis George, Salemis Nikolaos S
2nd Department of Surgery, Breast Unit, 401 General Army Hospital of Athens, Kanellopoulou and Katehaki Avenue, 11525 Athens, Greece.
Int J Surg Oncol. 2012;2012:653608. doi: 10.1155/2012/653608. Epub 2012 Dec 13.
Background. The objective of our study is to investigate the potential effect of adjusting preoperative platelet to lymphocyte ratio, an emerging biomarker of survival in cancer patients, for the fraction of large platelets. Methods. A total of 79 patients with breast neoplasias, 44 with fibroadenomas, and 35 with invasive ductal carcinoma were included in the study. Both conventional platelet to lymphocyte ratio (PLR) and the adjusted marker, large platelet to lymphocyte ratio (LPLR), were correlated with laboratory and histopathological parameters of the study sample. Results. LPLR elevation was significantly correlated with the presence of malignancy, advanced tumor stage, metastatic spread in the axillary nodes and HER2/neu overexpression, while PLR was only correlated with the number of infiltrated lymph nodes. Conclusions. This is the first study evaluating the effect of adjustment for large platelet count on improving PLR accuracy, when correlated with the basic independent markers of survival in a sample of breast cancer patients. Further studies are needed in order to assess the possibility of applying our adjustment as standard in terms of predicting survival rates in cancer.
背景。我们研究的目的是探讨调整术前血小板与淋巴细胞比值（一种癌症患者生存的新兴生物标志物）对大血小板比例的潜在影响。方法。本研究共纳入79例乳腺肿瘤患者，其中44例为纤维腺瘤，35例为浸润性导管癌。传统的血小板与淋巴细胞比值（PLR）和调整后的标志物大血小板与淋巴细胞比值（LPLR）均与研究样本的实验室和组织病理学参数相关。结果。LPLR升高与恶性肿瘤的存在、肿瘤晚期、腋窝淋巴结转移扩散以及HER2/neu过表达显著相关，而PLR仅与浸润淋巴结数量相关。结论。这是第一项评估在乳腺癌患者样本中，调整大血小板计数对提高PLR准确性的影响的研究，PLR与生存的基本独立标志物相关。需要进一步研究以评估将我们的调整方法作为预测癌症生存率的标准应用的可能性。
