Department of Cardiology, Baskent University, Faculty of Medicine, Adana, Turkey.
Clin Chem Lab Med. 2012 Apr;50(4):631-4. doi: 10.1515/CCLM.2011.806.
Studies on platelet function have accelerated and gained popularity since the advent of novel treatment modalities and techniques on atherosclerotic vascular disease, such as antiplatelet drugs and stents. Today it is widely known that platelets exert a fundamental role in inflammation in addition to their long known role in homeostasis and thrombotic events. Interaction with endothelial cells and leukocytes mediates inflammation, contributes to atherogenesis and modulates immune activity. Platelet activation which is a central factor in many arterial disorders may be triggered by multiple pathways. Platelet activation is shown as forming a larger shape, aggregation and releasing various active contents. Mean platelet volume is a marker of platelet size, function and activation. Increased mean platelet volume is shown by active and large platelets that release more thromboxane A2 than smaller ones. The aim of this review is to determine whether early detection of platelet activation via increased mean platelet volume would help to recognize the pro-inflammatory state and administer appropriate and effective treatment properly. An easily detectable marker by using a prompt and functional technique would help our approach to inflammation caused by platelets.
自抗血小板药物和支架等动脉粥样硬化血管疾病的新型治疗方法和技术问世以来，血小板功能的研究已经加速并受到关注。如今，人们普遍认识到，血小板除了在体内平衡和血栓形成事件中发挥着众所周知的作用外，还在炎症中发挥着基本作用。与内皮细胞和白细胞的相互作用介导炎症，促进动脉粥样硬化的发生，并调节免疫活性。血小板激活是许多动脉疾病的中心因素，可能通过多种途径触发。血小板激活表现为形成更大的形状、聚集和释放各种活性物质。平均血小板体积是血小板大小、功能和激活的标志物。较大的血小板释放更多的血栓素 A2，比小的血小板更容易激活。本综述的目的是确定通过增加平均血小板体积来早期检测血小板激活是否有助于识别促炎状态并进行适当和有效的治疗。使用快速和有效的技术来检测容易检测的标志物，将有助于我们了解由血小板引起的炎症。
