Heij Lara, Dahan Albert, Hoitsma Elske
Department of Anesthesiology, Leiden University Medical Center, P5Q, Postbus 9600, 2300 RC Leiden, The Netherlands.
Pain Res Treat. 2012;2012:256024. doi: 10.1155/2012/256024. Epub 2012 Dec 5.
Sarcoidosis is a chronic inflammatory illness and small-fiber neuropathy (SFN) is one of the disabling and often chronic manifestations of the disease. SFN presents with peripheral pain and symptoms of autonomic dysfunction. The character of the pain can be burning or shooting. Besides, allodynia and hyperesthesia can exist. Diagnosis is usually made on the basis of clinical features, in combination with abnormal specialized tests. The aim of treatment is often to reduce pain; however, total pain relieve is seldom achieved. The role of TNF-α in the pathogenesis of SFN in sarcoidosis appears interesting to explore. Novel therapeutic agents such as ARA 290, a nonhematopoietic erythropoietin analogue with potent anti-inflammatory and tissue protective properties, are interesting to explore in the treatment of SFN in sarcoidosis.
结节病是一种慢性炎症性疾病，小纤维神经病变（SFN）是该疾病致残且常为慢性的表现之一。SFN表现为外周疼痛和自主神经功能障碍症状。疼痛性质可为灼痛或刺痛。此外，还可能存在痛觉过敏和感觉异常。诊断通常基于临床特征，并结合异常的专科检查。治疗目的通常是减轻疼痛；然而，很少能完全缓解疼痛。探索肿瘤坏死因子-α（TNF-α）在结节病中SFN发病机制中的作用似乎很有意义。新型治疗药物，如具有强大抗炎和组织保护特性的非造血促红细胞生成素类似物ARA 290，在结节病SFN治疗中的探索很有意义。
