Raasing Lisette, Vogels Oscar J M, Veltkamp Marcel, Grutters Jan C
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ILD Center of Excellence, Department of Neurology, St Antonius Hospital (3435 CM, Nieuwegein, The Netherlands).
Sarcoidosis Vasc Diffuse Lung Dis. 2022 Dec 19;39(4):e2022033. doi: 10.36141/svdld.v39i4.12031.
Small fiber neuropathy (SFN) may present as complication in sarcoidosis.(1) SFN can potentially result into a large range of symptoms with a high impact on quality of life.(2) Although treatment of the underlying disease of SFN is paramount, little research has been performed to investigate SFN improvement as consequence of sarcoidosis treatment. This retrospective study investigates whether there is an association between the anti-inflammatory effects of infliximab and SFN-symptoms Methods: The Small Fiber Neuropathy Screening List (SFNSL) was used to measure changes in SFN symptoms during infliximab treatment. Maximal standardized uptake value (SUVmax) from Fluordeoxyglucose Positron Emission Tomography (FDG-PET) was used as a measure for inflammatory activity.
36 sarcoidosis patients were eligible for analysis. SFNSL-score showed a mean decrease of -1,9 points (p = 0.446). SUVmax did improve with a mean of -3.7 (p<0.001). No correlation between a decrease of SUVmax and SFNSL screening list could be found (p=0.610).
Our data reveal no association between anti-inflammatory effect of infliximab and SFN-related symptoms in patients with sarcoidosis, which contradicts previous case-reports and case-series.(3-6) Given the major negative impact of SFN-related symptoms on the quality of life in patients with sarcoidosis, it is necessary that the possible beneficial effect of anti-inflammatory therapy will be further addressed in future prospective studies.1.
小纤维神经病变（SFN）可能是结节病的并发症。（1）SFN可能导致一系列症状，对生活质量有很大影响。（2）虽然治疗SFN的基础疾病至关重要，但很少有研究探讨结节病治疗后SFN的改善情况。这项回顾性研究调查英夫利昔单抗的抗炎作用与SFN症状之间是否存在关联。方法：使用小纤维神经病变筛查清单（SFNSL）来测量英夫利昔单抗治疗期间SFN症状的变化。氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）的最大标准化摄取值（SUVmax）用作炎症活动的指标。
36例结节病患者符合分析条件。SFNSL评分平均下降-1.9分（p = 0.446）。SUVmax确实有所改善，平均下降3.7（p<0.001）。未发现SUVmax下降与SFNSL筛查清单之间存在相关性（p = 0.610）。
我们的数据显示，英夫利昔单抗的抗炎作用与结节病患者的SFN相关症状之间没有关联，这与之前的病例报告和病例系列研究结果相矛盾。（3-6）鉴于SFN相关症状对结节病患者生活质量有重大负面影响，有必要在未来的前瞻性研究中进一步探讨抗炎治疗可能产生的有益效果。1.
