Harb Ali N, Holtfreter Birte, Friedrich Nele, Wallaschofski Henri, Nauck Matthias, Kocher Thomas
Unit of Periodontology, Department of Restorative Dentistry, Periodontology, and Endodontology, Dental School, University Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald 17475, Germany.
ISRN Dent. 2012;2012:950486. doi: 10.5402/2012/950486. Epub 2012 Dec 6.
Aim. The aim was to compare the periodontal status of the acromegalic patients with healthy subjects from a large population-based cohort (Study of Health in Pomerania, SHIP). Materials and Methods. We studied 32 acromegalic patients (16 females) and 128 randomly selected SHIP subjects (controls) using a 1 : 4 matching. Serum IGF-I and IGFBP-3 levels were measured using the Immulite 2500 system. Periodontitis was assessed by clinical attachment loss (CAL), probing depth (PD), and number of missing teeth. Linear and logistic regression models were used to assess differences in periodontal variables between acromegalic patients and controls. Results. IGF-I levels were comparable in acromegalic patients and controls, whereas IGFBP-3 levels were significantly higher in acromegalic patients (P = 0.004). In multivariate modelling, both groups did not differ significantly with respect to mean CAL (P = 0.12) and high tooth loss (P = 0.36). Mean PD was higher in acromegalic patients by trend (B = 0.28 (-0.00; 0.56)). Conclusion. In acromegalic patients, periodontal disease severity did not differ from their healthy SHIP controls.
目的。目的是比较肢端肥大症患者与来自大型人群队列（波美拉尼亚健康研究，SHIP）的健康受试者的牙周状况。材料与方法。我们采用1∶4匹配的方式研究了32例肢端肥大症患者（16名女性）和128名随机选择的SHIP受试者（对照组）。使用Immulite 2500系统测量血清IGF-I和IGFBP-3水平。通过临床附着丧失（CAL）、探诊深度（PD）和缺失牙数量评估牙周炎。使用线性和逻辑回归模型评估肢端肥大症患者与对照组牙周变量的差异。结果。肢端肥大症患者和对照组的IGF-I水平相当，而肢端肥大症患者的IGFBP-3水平显著更高（P = 0.004）。在多变量建模中，两组在平均CAL（P = 0.12）和高牙齿缺失率（P = 0.36）方面无显著差异。肢端肥大症患者的平均PD呈上升趋势更高（B = 0.28（-0.00；0.56））。结论。在肢端肥大症患者中，牙周疾病严重程度与健康的SHIP对照组无差异。
