Szepesi S, Jacobi V, Vecsei P, Böttcher H D
Zentrum der Radiologie, Pharmakologisches Institut der Ruprecht-Karls-Universität Heidelberg.
Strahlenther Onkol. 1990 Apr;166(4):271-4.
20 patients with highly dosed irradiation of the small pelvis had been treated with Colifoam (hydrocortisone) in order to prove the therapeutic effect of radiation-induced proctitis. Over a period of three to six weeks starting in the third week of irradiation all patients received one applicator filling of rectal foam after bowel movement daily. The findings were verified by proctoscopy, histology and subjective personal well being. In ten patients we determined the daily cortisol profiles. Six months post irradiation ten patients underwent barium enema of the colon. During therapy no major complaints were recorded. The proctoscopic findings showed little changes concerning the submucous vascular walls. In none of the patients any kind of late lesion could be observed. The daily cortisol profile did not show any aberration of the physiological patterns. In conclusion the local therapy of Colifoam can be considered an additional treatment of radiation-induced colitis (proctitis).
为了证实辐射性直肠炎的治疗效果，对20例接受高剂量小骨盆照射的患者使用了可利肤（氢化可的松）进行治疗。从照射第三周开始的三到六周时间里，所有患者在每天排便后接受一次直肠泡沫剂灌肠。通过直肠镜检查、组织学检查和主观感受来验证结果。我们测定了10例患者的每日皮质醇水平。照射后六个月，10例患者接受了结肠钡灌肠检查。治疗期间未记录到严重不良反应。直肠镜检查结果显示黏膜下血管壁变化不大。所有患者均未观察到任何晚期病变。每日皮质醇水平未显示出生理模式的任何异常。总之，可利肤局部治疗可被视为辐射性结肠炎（直肠炎）的一种辅助治疗方法。
