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自膨式金属支架治疗慢性胰腺炎所致胆管梗阻的长期疗效

Long-term outcome of self expandable metal stents for biliary obstruction in chronic pancreatitis.

作者信息

Waldthaler Alexander, Schütte Kerstin, Weigt Jochen, Kropf Siegfried, Malfertheiner Peter, Kahl Stefan

机构信息

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany.

出版信息

JOP. 2013 Jan 10;14(1):57-62. doi: 10.6092/1590-8577/870.

Abstract

CONTEXT

Insertion of a self-expandable metal stent is still controversial for treatment of benign common bile duct stenosis but can be a valuable alternative to surgical treatment.

OBJECTIVE

Aim of our study was to analyze the efficacy of covered and uncovered self-expandable metal stent in patients with chronic pancreatitis and common bile duct stenosis.

MATERIAL AND METHODS

Twenty patients with common bile duct stenosis due to alcoholic chronic pancreatitis were retrospective analyzed. All patients had advanced chronic pancreatitis, presenting with calcifications in pancreatic head. Uncovered self-expandable metal stent (uSEMS) were used in 11 patients (3 females, 8 males) while in 9 patients (3 females, 6 males) partially covered self-expandable metal stent (cSEMS) were inserted. All patients treated with self-expandable metal stent had contraindications for surgery.

RESULTS

Overall mean follow up time was 155 weeks: 206 (52-412) weeks in uSEMS, and 93 (25-233) weeks in cSEMS, respectively. Stent patency was in mean 118 weeks: 159 (44-412) weeks in uSEMS and 67 (25-150) weeks in cSEMS (P=0.019). In the uSEMS group, reintervention was necessary in 5 patients (45%) due to stent obstruction, whereas in the cSEMS group 4 patients (44%) needed reintervention (2 obstructions, 2 migration). Stent migration is an early complication, compared to obstruction (P<0.05), and in cSEMS obstruction occurred significantly earlier compared to uSEMS (P<0.05).

CONCLUSION

Patency of uSEMS was significantly longer compared to partially cSEMS. Available self-expandable metal stent, unfortunately, do not meet the demands on successful treatment of benign common bile duct stenosis.

摘要

背景

对于良性胆总管狭窄的治疗,置入自膨式金属支架仍存在争议,但它可以成为手术治疗的一种有价值的替代方法。

目的

本研究旨在分析覆膜与非覆膜自膨式金属支架在慢性胰腺炎合并胆总管狭窄患者中的疗效。

材料与方法

对20例因酒精性慢性胰腺炎导致胆总管狭窄的患者进行回顾性分析。所有患者均为晚期慢性胰腺炎,胰头部有钙化。11例患者(3例女性,8例男性)使用了非覆膜自膨式金属支架(uSEMS),9例患者(3例女性,6例男性)置入了部分覆膜自膨式金属支架(cSEMS)。所有接受自膨式金属支架治疗的患者均有手术禁忌证。

结果

总体平均随访时间为155周:uSEMS组为206(52 - 412)周,cSEMS组为93(25 - 233)周。支架通畅时间平均为118周:uSEMS组为159(44 - 412)周,cSEMS组为67(25 - 150)周(P = 0.019)。在uSEMS组,5例患者(45%)因支架阻塞需要再次干预,而在cSEMS组,4例患者(44%)需要再次干预(2例阻塞,2例移位)。与阻塞相比,支架移位是一种早期并发症(P < 0.05),并且cSEMS组的阻塞发生时间明显早于uSEMS组(P < 0.05)。

结论

与部分覆膜的cSEMS相比,uSEMS的通畅时间明显更长。遗憾的是,现有的自膨式金属支架不能满足成功治疗良性胆总管狭窄的需求。

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