Grani G, Dicorato P, Dainelli M, Coletta I, Calvanese A, Del Sordo M, De Cesare A, Di Matteo F M, D'Andrea V, Fumarola A
Departments of Experimental Medicine, Unit of Endocrinology, Sapienza University, Rome, Italy.
Clin Ter. 2012 Nov;163(6):e401-4.
Several studies have been undertaken to investigate a possible link between breast cancer and thyroid diseases, notably thyroid carcinoma and autoimmune thyroid diseases, but the issue remains unresolved. The aim of this study is to evaluate, in thyropathic women with and without breast cancer, the following effects: the distribution of different thyroid diseases, the breast-cancer-related prevalence of anti-thyroperoxidase and anti-thyroglobulin antibodies and the role in thyroid pathology of breast-cancer post-surgery therapy with tamoxifene.
One-hundred-ninety thyropathic women with breast cancer (BC group) were recruited, and compared with a control group (C group) of one-hundred-ninety thyropathic women without breast cancer.
Nodular disease is the most frequent pathology in both groups. The difference in the incidence of thyroid carcinoma is also not statistically significant. The biochemical increase in the positivity of autoantibodies in BC-group patients is confirmed, but there is no statistically significant difference in the rate of clinical autoimmune diseases between the two groups. No difference in the frequency of any particular thyroid disease is found between those patients who underwent post-operative tamoxifene therapy and those who did not.
It can be concluded, on the basis of these results, that it is advisable to reduce the clinical weight of the issue. A routine thyroid screening is recommended in women with BC for the management of chronic comorbidities, as would be for women in the general population having the same age and coming from the same iodine-intake area.
已经开展了多项研究来调查乳腺癌与甲状腺疾病（尤其是甲状腺癌和自身免疫性甲状腺疾病）之间可能存在的联系，但该问题仍未得到解决。本研究的目的是评估患有和未患有乳腺癌的甲状腺疾病女性的以下情况：不同甲状腺疾病的分布、抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体与乳腺癌相关的患病率，以及他莫昔芬在乳腺癌术后治疗中对甲状腺病理的作用。
招募了190名患有乳腺癌的甲状腺疾病女性（BC组），并与190名未患有乳腺癌的甲状腺疾病女性对照组（C组）进行比较。
结节性疾病是两组中最常见的病理类型。甲状腺癌发病率的差异也无统计学意义。BC组患者自身抗体阳性率的生化升高得到证实，但两组临床自身免疫性疾病的发生率无统计学差异。接受术后他莫昔芬治疗的患者与未接受治疗的患者在任何特定甲状腺疾病的发生率上没有差异。
基于这些结果可以得出结论，建议降低该问题的临床重要性。对于患有乳腺癌的女性，建议进行常规甲状腺筛查以管理慢性合并症，这与来自相同碘摄入地区、年龄相同的普通人群中的女性一样。
