一种通用的固相合成去肽的方法。

A general solid phase method for the synthesis of depsipeptides.

机构信息

The University of Texas at Austin, Department of Biomedical Engineering, 107 W Dean Keeton Street, Austin, TX 78712, USA.

出版信息

Org Biomol Chem. 2013 Feb 21;11(7):1167-70. doi: 10.1039/c2ob26893k.

DOI:10.1039/c2ob26893k

PMID:23306773

Abstract

Herein we describe the synthesis of depsipeptide sequences in which the backbone is composed of alternating esters and amides. Our methodology is based on the synthesis and protection of a depsidipeptide block, which is used as the growing unit for manual SPPS. We have explored Fmoc/OBzl and Fmoc/tBu SPPS strategies, and found the latter to be most compatible with our methodology.

摘要

在此，我们描述了由酯和酰胺交替组成的多肽序列的合成。我们的方法基于 depsidipeptide 块的合成和保护，该块用作手动 SPPS 的增长单元。我们探索了 Fmoc/OBzl 和 Fmoc/tBu SPPS 策略，发现后者与我们的方法最兼容。