Department of Medicine, Central Hospital, Västerås, Sweden.
Metab Syndr Relat Disord. 2013 Apr;11(2):92-101. doi: 10.1089/met.2012.0100. Epub 2013 Jan 11.
High blood concentrations of inflammatory markers, including white blood cell (WBC) count, are closely related to the metabolic syndrome. Both conditions predict dismal survival. We determined prospective associations between mortality and factors derived by a factor analysis of WBC count and the basic components of the metabolic syndrome.
We performed a factor analysis of WBC count and the continuous components of the metabolic syndrome in 196 men and 200 women, comprising 64% of the originally invited 75 year olds from the Swedish city Västerås. The analysis revealed three factors in men and two in women. The first factor included fasting glucose, high-density lipoprotein cholesterol, triglycerides, and waist circumference in men and in addition WBC count in women. The second factor included diastolic blood pressure and systolic blood pressure in both sexes. In men, the third factor included fasting glucose and WBC count. These factors explained 66% (first factor, 28%; second factor, 23%; third factor, 15%) of the variation in men and 57% (first factor, 34%; second factor, 23%) in women. Prospective associations of the derived factors and all-cause mortality during 10-year follow-up were assessed by Cox regression [hazard ratio (HR)]. The first factor was significantly related to increased mortality in men: HR=1.22 [95% confidence interval (CI) 1.05-1.41; p=0.008] and women: HR=1.25 (95% CI 1.06-1.48; p=0.010). Pooling men and women adjusting for established cardiovascular risk factors gave HR=1.16 (95% CI 1.04-1.29; p=0.010). In men the third factor was significantly related to mortality; HR=1.29 (95% CI 1.07-1.57; p=0.009).
A metabolic inflammatory factor and a blood pressure factor were identified. In men, the former was split into a metabolic and an inflammatory factor. Factors including metabolic and inflammatory components were significantly related to 10-year mortality and the relation remained after adjusting for established cardiovascular risk factors.
炎症标志物（包括白细胞计数）的血液浓度较高与代谢综合征密切相关。这两种情况都预示着预后不良。我们通过对白细胞计数和代谢综合征基本成分的因子分析，确定了死亡率与因子之间的前瞻性关联。
我们对来自瑞典城市韦斯特罗斯的 196 名男性和 200 名女性中的 64%进行了白细胞计数和代谢综合征连续成分的因子分析。分析显示，男性有三个因子，女性有两个因子。男性中的第一个因子包括空腹血糖、高密度脂蛋白胆固醇、甘油三酯和腰围，女性中除了白细胞计数外还包括该因子。第二个因子包括男女的舒张压和收缩压。男性中的第三个因子包括空腹血糖和白细胞计数。这些因子解释了男性 66%（第一因子占 28%，第二因子占 23%，第三因子占 15%）和女性 57%（第一因子占 34%，第二因子占 23%）的变异。通过 Cox 回归[风险比（HR）]评估了衍生因子与 10 年随访期间全因死亡率的前瞻性关联。第一个因子与男性死亡率增加显著相关：HR=1.22[95%置信区间（CI）1.05-1.41；p=0.008]和女性：HR=1.25（95% CI 1.06-1.48；p=0.010）。调整了既定心血管危险因素后，男性和女性的 HR 为 1.16（95% CI 1.04-1.29；p=0.010）。男性中，第三个因子与死亡率显著相关；HR=1.29（95% CI 1.07-1.57；p=0.009）。
确定了一个代谢炎症因子和一个血压因子。在男性中，前者被分为代谢和炎症因子。包括代谢和炎症成分的因子与 10 年死亡率显著相关，并且在调整了既定心血管危险因素后仍然存在。
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