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青春期前后的人类乳房发育。

Peripubertal human breast development.

作者信息

Monaghan P, Perusinghe N P, Cowen P, Gusterson B A

机构信息

Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, England.

出版信息

Anat Rec. 1990 Apr;226(4):501-8. doi: 10.1002/ar.1092260412.

DOI:10.1002/ar.1092260412
PMID:2331062
Abstract

The microanatomical and histological appearance of the human breast has been studied during puberty. The macroscopic architecture of the mammary epithelial tree was identified and correlated with the histological appearance of material excised from defined regions of the breast preparations. Between ages 13 yrs and 15 yrs the human breast shows evidence of ductal elongation and branching, with lobules formed by lateral and dichotomous branching. The majority of ducts are lined by a two-layered epithelium consisting of recognisable myoepithelial and luminal cells. Less-well-defined multilayered regions were also observed in some areas, apparently at the site of lateral branching or early lobular development.

摘要

在青春期对人类乳腺的微观解剖学和组织学外观进行了研究。确定了乳腺上皮树的宏观结构,并将其与从乳腺制剂特定区域切除的材料的组织学外观相关联。在13岁至15岁之间,人类乳腺显示出导管伸长和分支的迹象,小叶由侧向和二叉分支形成。大多数导管由两层上皮细胞衬里,包括可识别的肌上皮细胞和管腔细胞。在一些区域也观察到定义不太明确的多层区域,显然是在侧向分支或早期小叶发育的部位。

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Anat Rec. 1990 Apr;226(4):501-8. doi: 10.1002/ar.1092260412.
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Breast Cancer Res Treat. 2018 Aug;170(3):487-497. doi: 10.1007/s10549-018-4768-0. Epub 2018 Mar 30.
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Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland.腔上皮细胞和肌上皮细胞之间连接蛋白的不对称表达对于乳腺的收缩功能至关重要。
Dev Biol. 2015 Mar 1;399(1):15-26. doi: 10.1016/j.ydbio.2014.11.026. Epub 2014 Dec 11.
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Development of the human breast.人类乳房的发育。
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