Kambam J R, Kinney W W, Matsuda F, Wright W, Holaday D A
Department of Anesthesiology, Vanderbilt University Hospital, Nashville, Tennessee 37232-2125.
Anesth Analg. 1990 May;70(5):543-5. doi: 10.1213/00000539-199005000-00013.
We studied the effects of epinephrine and phenylephrine on the cardiorespiratory toxicity of intravenously injected bupivacaine in Sprague-Dawley rats. Our data show that both epinephrine and phenylephrine significantly increased cardiorespiratory toxicity of intravenously injected bupivacaine (P less than 0.007, X2 analyses with Yates' correction). Our data suggest that epinephrine or phenylephrine added to bupivacaine may be more toxic to cardiorespiratory systems than plain bupivacaine or epinephrine alone or phenylephrine alone when injected intravenously in rats.
我们研究了肾上腺素和去氧肾上腺素对静脉注射布比卡因所致的Sprague-Dawley大鼠心肺毒性的影响。我们的数据显示，肾上腺素和去氧肾上腺素均显著增加了静脉注射布比卡因的心肺毒性（P<0.007，采用Yates校正的X2分析）。我们的数据表明，在大鼠静脉注射时，添加到布比卡因中的肾上腺素或去氧肾上腺素可能比单纯的布比卡因、肾上腺素或去氧肾上腺素对心肺系统更具毒性。
