Li Wei-Wei, Guo Hao, Fan Guan-Wei, Wang Xue-Mei
Research Room of Integrated Chinese and Western Medicine, Peking University First Hospital, Department of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing 100034, China.
Zhongguo Zhong Yao Za Zhi. 2012 Oct;37(20):3017-20.
The injury of exogenous formaldehyde and its merchanism have attracted wide attention from researchers. The latest study found that mammals have a whole system for generating and clearning formaldehyde. However, the imbalance on the system for generating and clearning formaldehyde for various reasons will cause abnormal accumulation of endogenous formaldehyde in vivo, which is closely related to learning diability and memory dysfunction. The increase in endogenous formaldehyde concentration may be one of factors inducing such neurodegenerative diseases as Alzheimer's disease. The study on the relationship between endogenous formaldehyde and such neurodegenerative diseases as Alzheimer's disease is of great significance and can provide new thoughts for preventing and treating Alzheimer's disease with traditional Chinese medicines.
外源性甲醛损伤及其机制已引起研究者的广泛关注。最新研究发现，哺乳动物拥有一套完整的甲醛生成和清除系统。然而，由于各种原因导致甲醛生成和清除系统失衡，会使体内内源性甲醛异常蓄积，这与学习障碍和记忆功能障碍密切相关。内源性甲醛浓度升高可能是诱发阿尔茨海默病等神经退行性疾病的因素之一。对内源性甲醛与阿尔茨海默病等神经退行性疾病之间关系的研究具有重要意义，可为运用中药防治阿尔茨海默病提供新思路。
