Department of Gynaecology, The Affiliated Tumour Hospital, Harbin Medical University, Harbin, China.
Biomarkers. 2013 Mar;18(2):136-43. doi: 10.3109/1354750X.2012.752526. Epub 2013 Jan 11.
A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) plays several crucial roles in carcinogenesis. In this case-control study, we investigated the relationship between LAPTM4B gene polymorphism and susceptibility to endometrial carcinoma (EC). In an adjusted multivariate logistic regression analyses, subjects with the LAPTM4B*1/2 and 2/2 genotypes respectively exhibited 1.572-fold (95% confidence interval (CI) = 1.041-2.375) and 2.335-fold (95% CI = 1.365-3.995) increases in the risk of developing EC relative to those carrying LAPTM4B1/1. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both p < 0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both p < 0.001). These results suggest that LAPTM4B polymorphisms might play an important role in the aetiology of EC.
一种新的基因称为 LAPTM4B（溶酶体相关蛋白跨膜 4β）在癌症发生中起着几个关键作用。在这项病例对照研究中，我们调查了 LAPTM4B 基因多态性与子宫内膜癌（EC）易感性之间的关系。在调整后的多变量逻辑回归分析中，与携带 LAPTM4B1/1 基因型的受试者相比，LAPTM4B1/2 和 2/2 基因型的受试者分别表现出 1.572 倍（95%置信区间（CI）=1.041-2.375）和 2.335 倍（95%CI=1.365-3.995）增加患 EC 的风险。携带 LAPTM4B2 的患者的总生存（OS）和无病生存（DFS）均明显缩短（均 p <0.001）。多变量分析显示，LAPTM4B 基因型是 OS 和 DFS 的独立预后因素（均 p <0.001）。这些结果表明，LAPTM4B 多态性可能在 EC 的发病机制中起重要作用。
